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Comment & Response |

Statin Use During Hospitalization for Intracerebral Hemorrhage—Reply

Alexander C. Flint, MD, PhD1
[+] Author Affiliations
1Kaiser Permanente Redwood City, Redwood City, California
JAMA Neurol. 2015;72(5):607-608. doi:10.1001/jamaneurol.2015.0134.
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In Reply Yang and Niu call attention to the important relationship between outpatient statin use prior to hospitalization for intracerebral hemorrhage and the impact of in-hospital statin use in our article.1 They are correct in underscoring how important it is to control for prior outpatient use, particularly with relation to issues regarding statin withdrawal.

As described in the Methods section,1 we carefully controlled for prior outpatient statin use in all of our models (except for models examining statin withdrawal, where all patients had received prior outpatient statin treatment). To control for prior outpatient statin use in our models, we determined outpatient use based on active prescriptions and pharmacy fills and required patients to have filled their statin prescription recently enough prior to their intracerebral hemorrhage admission to be classified as an outpatient statin user. We used this stringently determined measure of prior outpatient statin use as a covariate in our multivariable models.


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May 1, 2015
Yi Yang, MD, PhD; Peng-Peng Niu, MD
1Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China
JAMA Neurol. 2015;72(5):607. doi:10.1001/jamaneurol.2015.0131.
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