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Comment & Response |

Association Between Vaccines and Neuroinflammation—Reply

Annette Langer-Gould, MD, PhD1
[+] Author Affiliations
1Kaiser Permanente Southern California, Research and Evaluation, and Neurology, Pasadena, California
JAMA Neurol. 2015;72(5):605. doi:10.1001/jamaneurol.2015.75.
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In Reply We thank the authors for their thought-provoking letter regarding our article.1 To clarify, our data do not support the suggestion that vaccinations should be withheld or postponed from those individuals who have relatives with multiple sclerosis (MS) or radiologically isolated syndrome until brain imaging is performed as the risk for developing the first symptoms of MS 6 weeks after vaccination was not increased. In addition, we actually recommend the flu vaccine for our patients with MS because influenza illness is more likely to result in an MS relapse than influenza vaccination.2 We agree with the authors that vaccination in the midst of an MS relapse is not advised.

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May 1, 2015
Giovanni Ristori, MD, PhD; Rosella Mechelli, PhD; Marco Salvetti, MD
1Centre for Experimental Neurological Therapies, S. Andrea Hospital-Site, Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), Sapienza University, Rome, Italy
JAMA Neurol. 2015;72(5):605. doi:10.1001/jamaneurol.2015.71.
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