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Comment & Response |

Association Between Vaccines and Neuroinflammation Time, Risks, and Benefits

Giovanni Ristori, MD, PhD1; Rosella Mechelli, PhD1; Marco Salvetti, MD1
[+] Author Affiliations
1Centre for Experimental Neurological Therapies, S. Andrea Hospital-Site, Department of Neuroscience, Mental Health, and Sensory Organs (NESMOS), Sapienza University, Rome, Italy
JAMA Neurol. 2015;72(5):605. doi:10.1001/jamaneurol.2015.71.
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To the Editor We read with interest the work by Langer-Gould et al1 about the risk for demyelinating diseases after vaccinations. The major points of the article (no long-term risk for multiple sclerosis [MS] and short-term risk for neuroinflammation for any type of vaccination in younger individuals) suggest various levels of complexities.

Time (that is, age and time of vaccine administration) is important in the interplay between susceptible hosts and environmental factors.2 Previous work on the modeling of nondeterministic processes in MS development (random perturbations and time can amplify the effects of weak genetic and environmental factors)3 may provide a conceptual framework to interpret a timing effect of vaccines on neuroinflammation.

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May 1, 2015
Annette Langer-Gould, MD, PhD
1Kaiser Permanente Southern California, Research and Evaluation, and Neurology, Pasadena, California
JAMA Neurol. 2015;72(5):605. doi:10.1001/jamaneurol.2015.75.
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