Accepted for Publication: January 23, 2015.
Published Online: April 20, 2015. doi:10.1001/jamaneurol.2015.0098.
Study concept and design: Almeida, Schultz, Okonkwo.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Almeida, Schultz, Okonkwo.
Critical revision of manuscript for important intellectual content: All authors.
Statistical analysis: Almeida, Schultz, Okonkwo.
Obtained funding: Sager, Carlsson, Johnson, Asthana, Okonkwo.
Administrative, technical, or material support: Austin, Boots, Dowling, Gleason, Bendlin, Sager, Hermann, Zetterberg.
Study supervision: Okonkwo.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by grants K23 AG045957 (Dr Okonkwo), R01 AG031790 (Dr Carlsson), R01 AG021155 and R01 AG027161 (Dr Johnson), and P50 AG033514 (Dr Asthana) from the National Institute on Aging and by Clinical and Translational Science Award UL1RR025011 to the University of Wisconsin, Madison. Portions of this research were supported by the Wisconsin Alumni Research Foundation, Helen Bader Foundation, Northwestern Mutual Foundation, and Extendicare Foundation, as well as by the US Department of Veterans Affairs, including facilities and resources at the Geriatric Research Education and Clinical Center of the William S. Middleton Memorial Veterans Hospital, Madison. Mr Almeida’s yearlong study abroad at the University of Wisconsin, Madison, was funded by a scholarship from the Coordination for the Improvement of Higher Education Personnel (CAPES) Foundation.
Role of the Funder/Sponsor: The funders had no role with respect to design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.
Additional Contributions: We acknowledge the researchers and staff of the Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden, where the cerebrospinal fluid assays were performed. Importantly, we thank study participants in the Wisconsin Registry for Alzheimer’s Prevention and the Wisconsin Alzheimer’s Disease Research Center, without whom this work would not be possible.