Accepted for Publication: December 30, 2014.
Published Online: March 16, 2015. doi:10.1001/jamaneurol.2014.4821.
Study concept and design: Jack, Wiste, Weigand.
Acquisition, analysis, or interpretation of data: Jack, Wiste, Weigand.
Drafting of the manuscript: Jack, Wiste, Weigand, Knopman, Vemuri, Mielke, Lowe, Senjem, Gunter, Machulda, Pankratz, Rocca, Petersen.
Critical revision of the manuscript for important intellectual content: Jack, Wiste, Weigand, Knopman, Vemuri, Mielke, Lowe, Senjem, Gunter, Machulda, Pankratz, Rocca, Petersen.
Statistical analysis: Wiste, Weigand, Pankratz.
Administrative, technical, or material support: Senjem, Gunter, Gregg.
Conflict of Interest Disclosures: Dr Jack reported providing consulting services for Eli Lilly and reported receiving research funding from the National Institutes of Health (grants R01-AG011378, U01-AG024904, R01-AG041851, R01-AG37551, R01-AG043392, and U01-AG06786) and the Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Foundation. Dr Knopman reported serving as deputy editor for Neurology and on data safety monitoring boards for Lundbeck Pharmaceuticals and for the Dominantly Inherited Alzheimer Network (DIAN) study; reported being an investigator in clinical trials sponsored by TauRX Pharmaceuticals, Lilly Pharmaceuticals, and the Alzheimer’s Disease Cooperative Study; and reported receiving research support from the National Institutes of Health. Dr Lowe reported being a consultant for Bayer Schering Pharma and reported receiving research support from GE Healthcare, Siemens Molecular Imaging, Avid Radiopharmaceuticals, the National Institutes of Health (National Institute on Aging and National Cancer Institute), the Elsie and Marvin Dekelboum Family Foundation, the Minnesota Partnership for Biotechnology and Medical Genomics, and The Leukemia & Lymphoma Society. Dr Pankratz reported being funded by the National Institutes of Health (grants R01-AG040042, U01-AG06786, Mayo Clinic Alzheimer’s Disease Research Center/Core C P50-AG16574/Core C, and R01-AG32990). Dr Rocca reported serving on the editorial boards for Revista de Neurologia, Clinical Epidemiology & Risk Management, Maturitas, Menopause, and Journal of Chinese Clinical Medicine and reported receiving research support from the National Institutes of Health (grants R01-AG034676, U01-AG006786, P50-AG04417, and K12-HD065987). Dr Petersen reported serving on scientific advisory boards for Elan Pharmaceuticals, Wyeth Pharmaceuticals, and GE Healthcare; reported receiving royalties from publishing Mild Cognitive Impairment (Oxford University Press, 2003); and reported receiving research support from the National Institutes of Health (grants P50-AG16574, U01-AG06786, R01-AG11378, and U01-24904). No other disclosures were reported.
Funding/Support: This study was supported by grants R01-AG011378, R01-AG041851, and U01-AG06786 from the National Institute on Aging and by the Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Foundation.
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.