Accepted for Publication: December 12, 2014.
Published Online: March 16, 2015. doi:10.1001/jamaneurol.2014.4530.
Study concept and design: Mattsson, Insel.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Mattsson, Insel.
Critical revision of the manuscript for important intellectual content: Donohue, Jagust, Sperling, Aisen, Weiner.
Statistical analysis: Mattsson, Insel.
Obtained funding: Mattsson, Jagust, Weiner.
Study supervision: Jagust, Weiner.
Conflict of Interest Disclosures: Dr Sperling has served as a consultant to Boehringer-Ingelheim, Eisai, Genentech, Isis, Janssen, Lundbeck, Merck, and Roche and has received research support from the Alzheimer’s Association, Eli Lilly and Company, Janssen, and the National Institute on Aging. Dr Jagust serves as a consultant to Genentech and Synarc Inc. Dr Weiner has been on scientific advisory boards for BOLT International and Pfizer; has been a consultant for the Alzheimer’s Drug Discovery Foundation, Easton Associates, Harvard University, inThought Research, Janssen, KLJ Associates, Pfizer Inc, Sanofi-Aventis Groupe, and the University of California, Los Angeles; has received funding for travel from Alzheimer’s and Parkinson’s Diseases Congress, Danone Trading BV, MCI Group, France, Neuroscience School of Advanced Studies, Novartis, Paul Sabatier University, Pfizer, Tohoku University, Travel eDreams Inc, and Clinical Trials on Alzheimer’s Disease conference; serves as an associate editor of Alzheimer’s & Dementia; has received honoraria from Danone Trading BV, Pfizer, and Tohoku University; has received research support from Avid, Merck, the US Department of Defense, and the Veterans Administration; and has stock options in Elan and Synarc. No other conflicts were reported.
Funding/Support: Data collection and sharing for this project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) through grant U01 AG024904 from the National Institutes of Health [NIH] and award W81XWH-12-2-0012 from the US Department of Defense. The ADNI is funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute on Aging, and through generous contributions from the Alzheimer’s Association, Alzheimer’s Drug Discovery Foundation, Araclon Biotech, BioClinica Inc, Biogen Idec Inc, Bristol-Myers Squibb Company, Eisai Inc, Elan Pharmaceuticals Inc, Eli Lilly and Company, EuroImmun, F. Hoffmann-La Roche Ltd and its affiliated company Genentech Inc, Fujirebio, GE Healthcare, IXICO Ltd, Janssen Alzheimer Immunotherapy Research & Development LLC, Johnson & Johnson Pharmaceutical Research & Development LLC, Medpace Inc, Merck & Co Inc, Meso Scale Diagnostics LLC, NeuroRx Research, Neurotrack Technologies, Novartis Pharmaceuticals Corporation, Pfizer Inc, Piramal Imaging, Servier, Synarc Inc, and Takeda Pharmaceutical Company. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (http://www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer’s Disease Cooperative Study at the University of California, San Diego. The ADNI data are disseminated by the Laboratory for NeuroImaging at the University of Southern California. This research was also supported by grants P30 AG010129 and K01 AG030514 from the NIH, Carl-Bertil Laurells fond, Goteborgs Lakaresallskap, Klinisk Biokemi i Norden, Sahlgrenska Universitetssjukhuset, Svenska Lakaresallskapet, and the Swedish Research Council.
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: A complete listing of the ADNI investigators can be found in the eAppendix in the Supplement.