Accepted for Publication: December 23, 2014.
Published Online: March 9, 2015. doi:10.1001/jamaneurol.2014.4769.
Study concept and design: Rinaldi, Renvoise, De Michele, Santorelli, Filla, Casals, Traynor, Blackstone, Fischbeck.
Acquisition, analysis, or interpretation of data: Rinaldi, Schmidt, Situ, Johnson, Lee, Chen, Bott, Fadó, Harmison, Parodi, Grunseich, Biesecker, Stevanin, Dürr, Brice, Casals, Traynor, Fischbeck.
Drafting of the manuscript: Rinaldi, Casals, Blackstone, Fischbeck.
Critical revision of the manuscript for important intellectual content: Rinaldi, Schmidt, Situ, Johnson, Lee, Chen, Bott, Fadó, Harmison, Parodi, Grunseich, Renvoise, Biesecker, De Michele, Santorelli, Filla, Stevanin, Dürr, Brice, Casals, Traynor, Blackstone, Fischbeck.
Statistical analysis: Rinaldi, Schmidt, Situ, Johnson, Fadó, Casals, Traynor.
Obtained funding: Stevanin, Fischbeck.
Administrative, technical, or material support: Chen, Harmison, Renvoise, Biesecker, Fischbeck.
Study supervision: Casals, Fischbeck.
Conflict of Interest Disclosures: Dr Biesecker receives royalties from Amgen and Genentech and is an uncompensated advisor to the Illumina Corporation. No other disclosures were reported.
Funding/Support: This research was supported in part by the Intramural Research Program of the National Institutes of Health, National Institute of Neurological Disorders and Stroke, grant Z01-AG000949-02 from the National Institute on Aging (Drs Traynor and Johnson), the European Union’s Seventh Framework Programme for Research (Dr Brice), grant ANR-10-IAIHU-06 from the Investissements d’avenir (Drs Brice and Dürr), and the French Agency for Research (Dr Stevanin). Dr Lee is supported by funds from the Division of Intramural Research of the National Institute of Child Health and Human Development.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the DNA bank of the Institut du Cerveau et de la Moelle Épinière (coordinated by Sylvie Forlani, PhD, Neuroscience Research Center, Groupe Hospitalier Pitié-Salpêtrière, Paris, France) for technical assistance. No financial compensation was received.
Correction: This article was corrected on June 25, 2015, for typographical errors in Figure 1.