Accepted for Publication: November 3, 2014.
Published Online: February 23, 2015. doi:10.1001/jamaneurol.2014.4040.
Study concept and design: Chen, Li, Miller, Geschwind, Coppola.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Chen, Geschwind, Coppola.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Chen, Li, Coppola.
Obtained funding: Levenson, Ringman, DeCarli, Miller, Geschwind, Coppola.
Administrative, technical, or material support: Geschwind, Coppola.
Study supervision: Geschwind, Coppola.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was funded by grants from the National Institues of Health: F31 NS084556 (Mr Chen), P50 AG023501 (Dr Miller), RC1 AG035610 (Dr Coppola), R01 MH097268 (Dr Coppola), R01 AG26938 (Dr Geschwind), P01 AG019724 (Drs Levenson, B. L. Miller, and Geschwind), and R01 AG041762 (Dr Levenson); from the John Douglas French Alzheimer’s Foundation (Dr Coppola); the Tau Consortium (Drs Geschwind and Coppola); and the Jim Easton Consortium for Alzheimer’s Drug Discovery and Biomarker Development (Dr Ringman). We acknowledge the support of grant P30 NS062691 from the National Institute of Neurological Disorders and Stroke Informatics Center for Neurogenetics and Neurogenomics; grant P50 AG16570 from the University of California, Los Angeles, Alzheimer’s Disease Research Center; grant P50 AG016573 and POI AG000538 from the University of California, Irvine, Alzheimer’s Disease Research Center; grant P30 AG010129 from the University of California, Davis, Alzheimer’s Disease Center (Dr DeCarli); and grant P50 AG05142 from the University of Southern California Alzheimer’s Disease Research Center. Samples from the National Cell Repository for Alzheimer’s Disease, which receives government support under cooperative agreement grant U24 AG21886 from the National Institute on Aging, were used in this study. The National Alzheimer’s Coordinating Center database is funded by grant U01 AG016979 from the National Institute on Aging.
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Iris Vuong, BS, and Joseph DeYoung, BA (University of California, Los Angeles Neurosciences Genomics Core) assisted with array genotyping. Jean Paul Vonsattel, MD (New York Brain Bank at Columbia University) contributed brain specimens from patients with PSP that were used in the study. Bin Zhang, PhD, and Amanda Myers, PhD, assisted with the gene expression data. Margaret Chu, BS, and Maribel Estrada provided administrative support. We thank the contributors who collected samples used in this study. We especially thank the patients and their families, whose help and participation made this work possible and to whom our research is dedicated.