Accepted for Publication: September 18, 2014.
Published Online: February 23, 2015. doi:10.1001/jamaneurol.2014.3375.
Study concept and design: Rentz, Salmon, Ferris, Aisen, Sperling.
Acquisition, analysis, or interpretation of data: Amariglio, Donohue, Marshall, Ferris, Karantzoulis, Aisen, Sperling.
Drafting of the manuscript: Amariglio, Donohue.
Critical revision of the manuscript for important intellectual content: Donohue, Marshall, Rentz, Salmon, Ferris, Karantzoulis, Aisen, Sperling.
Statistical analysis: Amariglio, Donohue, Salmon.
Obtained funding: Aisen.
Administrative, technical, or material support: Aisen.
Study supervision: Rentz, Salmon, Aisen, Sperling.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by grant NIRG-12-243012 from the Alzheimer’s Association (Dr Amariglio) and grants U19 AG10483 (Dr Aisen), K24 AG035007 (Dr Sperling), P01 AG036694 (Dr Sperling), and K23AG044431 (Dr Amariglio) from the National Institutes of Health.
Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.
Alzheimer’s Disease Cooperative Study Group: Oregon Health Sciences University, Portland (Kathy Wild, PhD, and Georgene Siemjen, MS, RN); University of Southern California, Los Angeles (Lon Schneider, MD, and Alla Sverdlik); University of California at San Diego, La Jolla (Leon Thal, MD, and Mary Pay, RN, NP); Michigan Alzheimer's Disease Research Center, Ann Arbor (R. Scott Turner, MD, PhD, and Linda V. Nyquist, PhD); Mayo Clinic, Rochester MN (Ronald C. Petersen, PhD, MD, and Joan McCormick, BSN); Columbia University, New York, NY (Karen Bell, MD, and Ruth Tejeda, MD); Washington University, St Louis, MO (John Morris, MD, and Pamela Millsap, MSN); University of Alabama at Birmingham, Birmingham (Lindy Harrell, MD, PhD, and Jo Ann Parrish, LPN); Mt Sinai Medical Center, New York, NY (Karen Dahlman, PhD, and Adriana DiMatteo, MA); Rush Alzheimer's Disease Center, Chicago, IL (Neelum T. Aggaewal, MD, and Rose Marie Ferraro, LVN, AS); Wien Center for Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL (Ranjan Duara, MD, and Peggy D. Roberts); University Memory and Aging Center, Cleveland, OH (Paula Ogrocki, PhD, and Nancy A. Slocum, RN, MPH); Johns Hopkins University, Baltimore, MD (Cynthia Munro, PhD); University of South Florida, Tampa, FL (Eric Pfeiffer, MD, and Dorothy Baxter, MPH); New York University School of Medicine, New York, NY (Steven Ferris, PhD, and Nicole Martingano, BA); University of Pennsylvania, Philadelphia (Christopher Clark, MD, and Kris Gravanda, BA); University of Pittsburgh, Pittsburgh, PA (Judith Saxton, PhD, and Patrick Ketchel, MEd); University of Rochester, Rochester, NY (J. Michael Ryan, MD, and Colleen McCallim, MSW); University of California at Irvine, Irvine (Ruth Mulnard, DNSc, and Catherine McAdams-Ortiz, MSN); University of Texas Southwestern Medical Center, Dallas (Myron Weiner, MD, and Robbin Peck, AD); Emory University, Atlanta, GA (Felicia Goldstein, PhD, and Lisa Kilpatrick, MS); University of California at Los Angeles, Los Angeles (John Ringman, MD, and Susan O'Connor, RNC); Mayo Clinic, Jacksonville, FL (Neill Graff-Radford, MD, and Francine Parfitt, MSH, CCRC); Indiana University Alzheimer's Center, Indianapolis (Martin Farlow, MD, and Nicki Coleman, RN); Memorial Hospital of Rhode Island (Brown), Pawtucket (Brian Ott, MD, and Michael Pimental, CMA); Yale University, New Haven, CT (Christopher van Dyck, MD, and Martha MacAvoy, PhD); University of California at Davis, Sacramento (Charles DeCarli, MD, and Bobbi Henk, RN, MSN); Baumel-Eisner, Boca Raton, FL (Larry Eisner, MD, and Rebecca Radzivill, MS); Baumel-Eisner, Ft Lauderdale, FL (Barry Baumel, MD, and Magdalena Szymczak); Baumel-Eisner, Miami Beach, FL (Beth Safirstein, MD, and Melissa Perez-Velasco, BS); University of Nevada at Las Vegas, Las Vegas (Charles Bernick, MD, and Marie L. Stallbaum, BSN); Northwestern University, Chicago, IL (M. Marsel Mesulam, MD, and Laura Herzog, MA); The Medical University of South Carolina, North Charleston (Jacobo Mintzer, MD, and Effie Hatchett, RNC); Georgetown University, Washington, DC (Paul S. Aisen, MD, and Carolyn Ward, MSPH); Brigham and Women's Hospital, Boston, MA (Reisa Sperling, MD, MMSc, and Kara Campoba, MA, PA); Stanford/Veterans Affairs Aging Clinical Research Center, Palo Alto, CA (Joy Taylor, PhD, and Heather Fiedler-Greene, MA); Sun Health Research Institute, Sun City, AZ (Donald Connor, PhD, and Suhair Stipho, MB, CHB); Boston University School of Medicine, Boston, MA (Robert C. Green, MD, PhD, and Mary-Tara Roth, RN, MSN, MPH).
Additional Contributions: We acknowledge the staff of the ADCS, the site personnel from the ADCS–Prevention Instrument Trial, and all the participants who dedicated their time to this study.
Correction: This article was corrected on March 9, 2015, to fix an error in Figure 1.