We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Neurology |

Highlights FREE

JAMA Neurol. 2015;72(2):139. doi:10.1001/jamaneurol.2014.2831.
Text Size: A A A
Published online


Rotstein and coauthors investigate no evidence of disease activity (NEDA) during 7 years as measured by relapses, disability progression, and yearly magnetic resonance imaging (MRI). They decided that NEDA was defined as a composite that consisted of absence of relapses, no sustained Expanded Disability Status Scale score progression, and no new or enlarging T2 or T1 gadolinium-enhancing lesions on annual MRI. They report that NEDA is difficult to sustain long term even with treatment. Editorial perspective is provided by Jaime Imitola, MD, and Michael K. Racke, MD.

Nash and colleagues evaluate the safety, efficacy, and durability of multiple sclerosis (MS) disease stabilization through 3 years after high-dose immunosuppressive therapy (HDIT) with autologous hematopoietic cell transplant (HCT). Autologous peripheral blood stem cell grafts were CD34+ selected; the participants then received high-dose treatment with carmustine, etoposide, cytarabine, and melphalan as well as rabbit antithymocyte globulin before autologous HCT. At 3 years, HDIT/HCT without maintenance therapy was effective for inducing sustained remission of active relapsing-remitting MS and was associated with improvements in neurologic function. Editorial perspective is provided by M. Mateo Paz Soldán, MD, PhD, and Brian G. Weinshenker, MD.

Martinez-Hernandez et al investigate the frequency of antibodies to aquaporin 4 (AQP4), myelin-oligodendrocyte glycoprotein (MOG), and the glycine receptor α1 subunit (GlyR) in patients with unilateral or bilateral, severe, or recurrent isolated optic neuritis (ON) and determine their clinical and prognostic correlates. They determined the presence of antibodies to AQP4, MOG, and GlyR using cell-based assays. They report that 45% of patients with unilateral or bilateral, severe, or recurrent isolated ON had antibodies to MOG, AQP4, or GlyR.


Rajan and coauthors review existing data on prehospital stroke treatment, especially relevant to mobile stroke unit (MSU) technology. They review published data from English-language journals in PubMed from 1995 to present reviewing early treatment with tissue plasminogen activator and prehospital stroke evaluation and treatment. The MSU strategy could dramatically transform the way acute stroke is managed in the United States.

Stenudd and colleagues indicate that spinal cord injury is followed by glial scar formation, which has positive and negative effects on recovery from the lesion. They demonstrated that the neural stem cell–derived scar component has several beneficial functions, including restricting tissue damage and neural loss after spinal cord injury. This finding identifies endogenous neural stem cells as a potential therapeutic target for treatment of spinal cord injury.





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Related Content

Customize your page view by dragging & repositioning the boxes below.