Accepted for Publication: October 30, 2014.
Published Online: January 26, 2015. doi:10.1001/jamaneurol.2014.3974.
Study concept and design: Monserrate, Ryman, Masters, Salloway, Bateman.
Acquisition, analysis, or interpretation of data: Monserrate, Ryman, Ma, Xiong, Noble, Ringman, Morris, Danek, Müller-Sarnowski, Clifford, McDade, Brooks, Darby, Weston, Farlow, Graff-Radford, Salloway, Fagan, Oliver, Bateman.
Drafting of the manuscript: Monserrate, Ryman, Bateman.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Monserrate, Ryman, Ma, Xiong, Müller-Sarnowski, Bateman.
Obtained funding: Morris, Masters, Bateman.
Administrative, technical, or material support: Noble, Morris, Clifford, Farlow, Fagan, Oliver, Bateman.
Study supervision: Ryman, Bateman.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by Washington University Institute of Clinical and Translational Sciences grants UL1 TR000448 and TL1 TR000449 from the National Center for Advancing Translational Sciences. The Dominantly Inherited Alzheimer Network (DIAN) is supported by grant U19 AG032438 from the National Institute on Aging (Dr Morris) and by the generous support of F. Simmons and O. Mohan, in addition to DIAN site support from the German Center for Neurodegenerative Diseases, the National Institute for Health Research Queen Square Dementia Biomedical Research Unit, and J. O. and J. R. Wicking Trust grants 13026 and 20821.
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: The Dominantly Inherited Alzheimer Network investigators are listed at http://www.dian-info.org.17
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Additional Contributions: We gratefully acknowledge the contributions of all participants and family members involved in this research.