0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

The Translational Journey of Brain β-Amyloid Imaging From Positron Emission Tomography to Autopsy to Clinic

Gil D. Rabinovici, MD1
[+] Author Affiliations
1Memory and Aging Center, Department of Neurology, University of California–San Francisco
JAMA Neurol. 2015;72(3):265-266. doi:10.1001/jamaneurol.2014.4143.
Text Size: A A A
Published online

Extract

More than a decade ago, Klunk and colleagues1 published the first study applying the positron emission tomography (PET) ligand carbon 11–labeled Pittsburgh Compound B to image amyloid-β (Aβ) plaques in patients with Alzheimer disease (AD). In subsequent years, amyloid PET has had a transformative impact on AD research, leading to refined models of disease pathogenesis, providing in vivo evidence for a prolonged preclinical disease phase, and ultimately setting the stage for therapeutic trials aimed at delaying or even preventing the symptomatic phase of AD.2,3 Beyond research applications, amyloid PET has great potential as a diagnostic tool. The clinical diagnosis of AD, even in the hands of experts, has only moderate sensitivity and specificity when compared with the pathological cause of dementia as determined at autopsy.4 Misdiagnosis rates approaching 30% have implications for patient care and may be a major confounder in AD clinical trials.5 Amyloid PET has the potential to improve diagnostic accuracy by directly detecting a core element of AD pathology. While carbon 11–labeled Pittsburgh Compound B has limited prospects as a clinical diagnostic given the short half-life of the carbon 11 radioisotope (20 minutes), a number of Aβ PET tracers radiolabelled with fluorine 18 (18F), a longer-lived isotope (half-life = 110 minutes) used extensively in nuclear medicine, have been developed for clinical applications.6 These include [18F]flutemetamol, an 18F-labeled derivative of Pittsburgh Compound B that performed comparably with the parent compound in initial clinical studies.7

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

887 Views
1 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();