Accepted for Publication: November 25, 2014.
Published Online: February 2, 2015. doi:10.1001/jamaneurol.2014.4354.
Study concept and design: Romano, Smith, Gardener, Camp, Shuey, Campo-Bustillo, Sacco, Schwamm.
Acquisition, analysis, or interpretation of data: Romano, Smith, Liang, Gardener, Camp, Shuey, Cook, Khatri, Bhatt, Fonarow, Schwamm.
Drafting of the manuscript: Romano, Smith, Khatri, Bhatt, Fonarow.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Liang, Gardener.
Obtained funding: Romano.
Administrative, technical, or material support: Romano, Smith, Camp, Shuey, Cook, Campo-Bustillo, Fonarow, Sacco.
Study supervision: Romano, Shuey, Cook, Khatri, Schwamm.
Conflict of Interest Disclosures: Dr Romano reported receiving research salary support from Genentech and serving on the scientific advisory board for Vycor/NovaVision. Dr Smith reported serving on the data safety monitoring board of an alteplase trial funded by the National Institute of Neurological Disorders and Stroke. Dr Gardener reported receiving research salary support from Genentech. Dr Campo-Bustillo reported receiving research salary support from Genentech. Dr Khatri reported receiving research salary support from Genentech, Penumbra, and Biogen; honorarium from UpToDate; and book royalties from Taylor and Francis. Dr Bhatt reported serving on the advisory boards for Elsevier PracticeUpdate Cardiology, Medscape Cardiology, and Regado Biosciences; serving on the board of directors of the Boston VA Research Institute and the Society of Cardiovascular Patient Care; serving as chair on the American Heart Association Get With the Guidelines steering committee; serving on data monitoring committees for Duke Clinical Research Institute, Harvard Clinical Research Institute, Mayo Clinic, Population Health Research Institute; receiving honoraria from the American College of Cardiology (editor, Clinical Trials, Cardiosource), Belvoir Publications (editor in chief, Harvard Heart Letter), Duke Clinical Research Institute (clinical trial steering committees), Harvard Clinical Research Institute (clinical trial steering committee), HMP Communications (editor in chief, Journal of Invasive Cardiology), Population Health Research Institute (clinical trial steering committee), Slack Publications (chief medical editor, Cardiology Today’s Intervention), and WebMD (continuing medical education steering committees); serving as deputy editor of Clinical Cardiology and pharmacology section editor of the Journal of the American College of Cardiology; receiving research grants from Amarin, AstraZeneca, Bristol-Myers Squibb, Eisai, Ethicon, Medtronic, Roche, Sanofi-Aventis, and The Medicines Company; and performing unfunded research for FlowCo, PLx Pharma, and Takeda. Dr Fonarow is an employee of the University of California, which holds a patent on a retriever device for stroke. Dr Sacco reported serving as a consultant to Boehringer-Ingelheim. Dr Schwamm reported serving as the principal investigator of a National Institute of Neurological Disorders and Stroke–funded study for which Genentech provides alteplase and supplementary site payments and serving as a member of the international steering committee of desmoteplase trials for Lundbeck. No other disclosures were reported.
Funding/Support: This work was supported by a grant from Genentech to the University of Miami.
Role of the Funder/Sponsor: Genentech had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentation: This work was presented in part as a poster at the International Stroke Conference 2014; February 12, 2014; San Diego, California.