Accepted for Publication: November 6, 2014.
Published Online: February 2, 2015. doi:10.1001/jamaneurol.2014.4103.
Study concept and design: Drachman, Traynor.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Drachman, Traynor.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Renton, Nalls, Gibbs, Drachman, Traynor.
Obtained funding: Drachman, Traynor.
Administrative, technical, or material support: Provenzano, Evoli, Ricciardi, Hernandez, Bartoccioni, Scuderi, Maestri, Errichiello, Macek, Scholz, Corse, Benatar, Barohn, Pasnoor, Rowin, Kissel, Massey, Chopra, Koopman, Nicolle, Pestronk, Wulf, Florence, Soloway, Wolfe, Jiwa, Oger, Drachman, Traynor.
Study supervision: Drachman, Traynor.
Conflict of Interest Disclosures: None reported.
Funding/Support: The work was supported by the Myasthenia Gravis Foundation (Drs Drachman and Traynor), a generous bequest by Geraldine Weinrib, and a gift from Philip Swift. This work was also supported in part by the Intramural Research Programs of the National Institutes of Health National Institute on Aging (Z01-AG000949-02).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the patients and research participants who contributed samples for this study.
Additional Information: This study used the high-performance computational capabilities of the Biowulf Linux cluster at the National Institutes of Health, Bethesda, Maryland (http://biowulf.nih.gov).