Accepted for Publication: October 30, 2014.
Published Online: January 19, 2015. doi:10.1001/jamaneurol.2014.3978.
Study concept and design: Kaup, Yaffe.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Kaup, Yaffe.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Kaup, Nettiksimmons, Yaffe.
Obtained funding: Harris, Yaffe.
Administrative, technical, or material support: Satterfield, Ayonayon.
Study supervision: Yaffe.
Conflict of Interest Disclosures: Dr Sink serves on 2 data safety and monitoring boards (DSMBs) for studies sponsored by the National Institutes of Health (NIH) and is the site principal investigator for an industry-sponsored clinical trial (Sponsor Navidea Biopharmaceuticals). Dr Yaffe is a consultant for Novartis and Pfizer; serves on DSMBs for Takeda, Inc, and a study sponsored by the National Institute on Aging (NIA); and serves on the Beeson Scientific Advisory Board. No other disclosures were reported.
Funding/Support: This study was supported by contracts N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106 and grant R01-AG028050 from the NIA; by grant R01-NR012459 from the National Institute on Nursing Research; and in part by the Intramural Research Program of the NIA/NIH, all of which supported the design and conduct of the study; collection, management, analysis, and interpretation of the data; and review and approval of the manuscript. This study was also supported by grant K24AG031155 from the NIA (Dr Yaffe), which supported the design and conduct of the study, analysis and interpretation of the data, preparation and review of the manuscript, and decision to submit the manuscript for publication. Preparation of the manuscript was supported by the Department of Veterans Affairs Office of Academic Affiliations Advanced Fellowship Program in Mental Illness Research and Treatment, the Medical Research Service of the San Francisco Veterans Affairs Medical Center, and the Sierra Pacific Mental Illness Research, Education, and Clinical Center.
Role of the Funder/Sponsor: The NIA was involved in the design and conduct of the study; data collection and management; and the review and approval of the manuscript.
Group Information: Principal investigators for the ABC Health Study included Tamara B. Harris, MD, National Institute on Aging (lead investigator); Melissa E. Garcia, MPH, National Institute on Aging; Anne B. Newman, MD, MPH, University of Pittsburgh, Pittsburgh, Pennsylvania; Suzanne Satterfield, MD, DrPH, University of Tennessee, Memphis; Steven R. Cummings, MD, University of California, San Francisco; and Michael C. Nevitt, PhD, University of California, San Francisco. Health ABC Study coordinators were Diane Ives, MPH, University of Pittsburgh, and Jan Elam, BS, University of Tennessee, Memphis. Health ABC project director was Susan M. Rubin, MPH, University of California, San Francisco.