Accepted for Publication: October 1, 2014.
Published Online: January 19, 2015. doi:10.1001/jamaneurol.2014.3625.
Study concept and design: Han, Baxter, Reiman, Shi.
Acquisition, analysis, or interpretation of data: Han, Caselli, Serrano, Yin, Beach, Reiman, Shi.
Drafting of the manuscript: Han, Shi.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Han, Shi.
Obtained funding: Han, Beach, Reiman, Shi.
Administrative, technical, or material support: Han, Caselli, Serrano, Yin, Beach.
Study supervision: Han, Reiman.
Conflict of Interest Disclosures: None reported.
Funding/Support: Funding was provided by the Arizona Alzheimer’s Consortium (National Institutes of Health/National Institute on Aging grant P30 AG19610 and the state of Arizona), the Barrow Neurological Foundation, and a joint translational neuroscience grant from the Barrow Neurological Institute and University of Arizona, Phoenix.
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We are grateful for patients who donated their brains as well as for their families.