Accepted for Publication: November 4, 2014.
Published Online: January 5, 2015. doi:10.1001/jamaneurol.2014.4068.
Study concept and design: Dorey, Perret-Liaudet, Kovacs, Quadrio.
Acquisition, analysis, or interpretation of data: Dorey, Tholance, Vighetto, Lachman, Krolak-Salmon, Wagner, Struyfs, De Deyn, El-Moualij, Zorzi, Meyronet, Streichenberger, Engelborghs, Quadrio.
Drafting of the manuscript: Dorey, Vighetto, Perret-Liaudet, Kovacs, Quadrio.
Critical revision of the manuscript for important intellectual content: Dorey, Tholance, Vighetto, Perret-Liaudet, Lachman, Krolak-Salmon, Wagner, Struyfs, De Deyn, El-Moualij, Zorzi, Meyronet, Streichenberger, Engelborghs, Kovacs, Quadrio.
Statistical analysis: Dorey, Tholance.
Obtained funding: Perret-Liaudet, Lachman, El-Moualij, Zorzi, Kovacs.
Administrative, technical, or material support: Lachman, Wagner, Struyfs, De Deyn, El-Moualij, Streichenberger, Engelborghs.
Study supervision: Dorey, Vighetto, Perret-Liaudet, Quadrio.
Conflict of Interest Disclosures: Drs Lachman and Wagner are employees of the diagnostic company AJ Roboscreen. Drs Perret-Liaudet and Engelborghs served on the scientific advisory board for Innogenetics/Fujirebio Europe. Prof Vighetto received a travel grant from Innogenetics. No other disclosures were reported.
Funding/Support: This work was supported by grant LSHB-CZ-2006-037719 from EU FP6 Project Neuroscreen (Dr Quadrio), by the University of Antwerp Research Fund, the Alzheimer Research Foundation, the Research Foundation Flanders, the Agency for Innovation by Science and Technology, the Belgian Science Policy Office Interuniversity Attraction Poles program, and the Flemish government-initiated Methusalem Excellence Grant, Belgium (Drs Engelborghs, De Deyn, and Struyfs). The Center for Memory Resources and Research is supported by the French Alzheimer Plan.
Role of the Funder/Sponsor: The funders provided financial support for research but had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the patients and their families for their participation and encouragement as well as the clinicians. Particular thanks to CRB-HCL-Cardiobiotec, Valentine Minangoy, BS, Anne-Cécile Chiollaz, PharmD, Françoise Didier, AD, Elisabeth Barbey, AD, and Céline Béraud, AD, Hospices Civils de Lyon, Groupement Hospitalier Est, Department of Biochemistry, Neurochemistry Unit, Lyon, France; Marion Ménard-Ruiz, MSc; and Bernard Renaud, PhD, for their technical support. We are grateful to Jean-Jacques Martin, PhD, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium, for the neuropathology of the Antwerp patients with AD included in this study. None of the individuals received compensation for their contributions with the exception of Marion Menard-Ruiz for her translation service.