Accepted for Publication: October 2, 2014.
Published Online: December 22, 2014. doi:10.1001/jamaneurol.2014.3537.
Study concept and design: Rotstein, Weiner.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Rotstein.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Rotstein, Healy.
Obtained funding: Weiner.
Administrative, technical, or material support: Malik, Chitnis, Weiner.
Study supervision: Chitnis, Weiner.
Conflict of Interest Disclosures: Dr Rotstein reported receiving research support from the Multiple Sclerosis Society of Canada and serving as a consultant for sanofi-aventis. Dr Healy reported receiving grant support from Merck Serono and Novartis. Dr Malik reported receiving grant support from Merck Serono. Dr Chitnis reported serving as a consultant for Biogen-Idec, Novartis, and Alexion and receiving grant support from EMD Serono and Novartis. Dr Weiner reported receiving personal compensation for consulting and speaking activities and serving on the scientific advisory board of companies, including Biogen Idec, Novartis, EMD Serono, Teva Neurosciences, GSK, Nasvax, Xenoport, and Genzyme. He also reported receiving grant support from EMD Serono. No other disclosures were reported.
Funding/Support: Merck Serono provided partial financial support for data collection and reviewed the manuscript.
Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, or approval of the manuscript; and the decision to submit the manuscript for publication.