Accepted for Publication: August 4, 2014.
Published Online: December 15, 2014. doi:10.1001/jamaneurol.2014.2757.
Study concept and design: Bohnen, Muller, Frey.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Bohnen, Albin.
Critical revision of the manuscript for important intellectual content: Muller, Petrou, Kotagal, Koeppe, Scott, Frey.
Statistical analysis: Bohnen, Kotagal, Koeppe.
Obtained funding: Bohnen, Albin, Frey.
Administrative, technical, or material support: Albin, Muller, Petrou, Frey.
Study supervision: Bohnen, Albin, Muller, Koeppe, Scott.
Conflict of Interest Disclosures: Dr Albin serves on the editorial boards of Neurology, Experimental Neurology, and Neurobiology of Disease; receives grant support from the Cure Huntington’s Disease Initiative; and serves on the data safety and monitoring boards of the TV7820-CNS-20002 trial. Dr Petrou received research support from the Radiological Society of North America. Dr Kotagal receives research support from the American Academy of Neurology Clinical Research Training Fellowship. Dr Koeppe receives research support from the National Institutes of Health (National Institute of Neurological Disorders and Stroke, National Institute on Aging). Dr Scott receives editorial royalties from Wiley; is an owner of SynFast Consulting, LLC; and has received research funding from the University of Michigan, GE Healthcare, Bristol-Myers Squibb, Bayer Pharma AG, Eli Lilly, and Molecular Imaging Research. Dr Frey receives research support from the National Institutes of Health, GE Healthcare, and AVID Radiopharmaceuticals (Eli Lilly subsidiary). Dr Frey also serves as a consultant to AVID Radiopharmaceuticals; MIMVista, Inc; Bayer-Schering; and GE Healthcare. He also holds equity (common stock) in GE, Bristol-Myers, Merck, and Novo-Nordisk.
Funding/Support: This work was supported by grant I01 RX000317 from the Department of Veterans Affairs, the Michael J Fox Foundation, and grants P01 NS015655 and RO1 NS070856 from the National Institutes of Health.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: The authors thank all patients for their time commitment and research assistants, positron emission tomography technologists, cyclotron operators, and chemists for their assistance with the study.