Accepted for Publication: May 22, 2014.
Published Online: November 24, 2014. doi:10.1001/jamaneurol.2014.1753.
Study concept and design: Gorman, Pfeffer, Horvath, Chinnery, Taylor.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Gorman, Pfeffer, Schoser, Horvath, Chinnery, Taylor.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Pfeffer, Kurzawa-Akanbi, Sitarz.
Obtained funding: Turnbull, Chinnery, Taylor.
Administrative, technical, or material support: Kurzawa-Akanbi, Gabriel, Roberts, Schoser, Pyle, Schaefer.
Study supervision: Gorman, Pfeffer, Turnbull, Horvath, Chinnery, Taylor.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by the UK National Health Service (NHS) Specialised Service for Rare Mitochondrial Diseases of Adults and Children, Newcastle, and the National Institute for Health Research (NIHR) Biomedical Research Centre funding scheme based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. Drs Turnbull, Chinnery, and Taylor receive support from the Wellcome Trust Centre for Mitochondrial Research (096919Z/11/Z). Drs Taylor, Horvath, McFarland, Turnbull, and Gorman receive support from the Medical Research Council (UK) Centre for Translational Muscle Disease Research (G0601943). Drs Taylor, McFarland, and Turnbull are supported by the Medical Research Council (UK) Mitochondrial Disease Patient Cohort (G0800674) and the UK NHS Highly Specialised Rare Mitochondrial Disorders of Adults and Children Service. Dr Pfeffer is the recipient of a Bisby Fellowship from the Canadian Institutes of Health Research. Dr Chinnery is a Wellcome Trust senior fellow in clinical science (084980/Z/08/Z) and a UK NIHR senior investigator and receives additional support from EU FP7 TIRCON. Drs Turnbull and Chinnery are also funded by the NIHR Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.