Accepted for Publication: September 4, 2014.
Published Online: November 17, 2014. doi:10.1001/jamaneurol.2014.3188.
Study concept and design: Ebinger, Audebert.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Ebinger, Audebert.
Critical revision of the manuscript for important intellectual content: Kunz, Wendt, Rozanski, Winter, Waldschmidt, Weber, Villringer, Fiebach, Audebert.
Statistical analysis: Audebert.
Obtained funding: Audebert.
Administrative, technical, or material support: Ebinger, Kunz, Wendt, Waldschmidt, Weber, Villringer.
Study supervision: Ebinger, Fiebach, Audebert.
Conflict of Interest Disclosures: Dr Audebert received speaker honoraria from Boehringer Ingelheim, the manufacturer of alteplase (not involved in this trial), and speaker and consultancy honoraria from Lundbeck A/S, which has conducted a recent acute stroke thrombolysis trial. No other disclosures were reported.
Funding/Support: The PHANTOM-S study was supported by the Zukunftsfonds Berlin and the Technology Foundation Berlin with cofinancing by the European Regional Development Fund.
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Ulrike Grittner, PhD, Center for Stroke Research Berlin, Charité–Universitätsmedizin Berlin, provided statistical advice. He received no compensation for this contribution.