Accepted for Publication: August 29, 2014.
Published Online: November 3, 2014. doi:10.1001/jamaneurol.2014.3049.
Study concept and design: Yu, Chibnik, Pochet, Meissner, De Jager, Bennett.
Acquisition, analysis, or interpretation of data: Yu, Chibnik, Srivastava, Pochet, Xu, Kozubek, Obholzer, Schneider, Meissner, De Jager, Bennett.
Drafting of the manuscript: Yu, Pochet.
Critical revision of the manuscript for important intellectual content: Chibnik, Srivastava, Pochet, Yang, Xu, Kozubek, Obholzer, Leurgans, Schneider, Meissner, De Jager, Bennett.
Statistical analysis: Yu, Yang, Leurgans.
Obtained funding: Schneider, De Jager, Bennett.
Administrative, technical, or material support: All authors.
Study supervision: Pochet, Bennett.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by grants P30AG10161, R01AG15819, R01AG17917, R01AG36042, R01AG36836, and U01AG46152 from the National Institutes of Health.
Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank all the participants of the Religious Orders Study and the Rush Memory and Aging Project, as well as the staff at the Rush Alzheimer’s Disease Center, for this work.