We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Exploring the Epigenetics of Alzheimer Disease

Bryan J. Traynor, MD, PhD1,2; Alan E. Renton, PhD1
[+] Author Affiliations
1Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland
2Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland
JAMA Neurol. 2015;72(1):8-9. doi:10.1001/jamaneurol.2014.3057.
Text Size: A A A
Published online


Genome-wide association studies have been tremendously successful at unraveling the genetic architecture of neurological disorders (see http://www.genome.gov/gwastudies/ for an updated list). Alzheimer disease is a particularly good example of the power of this technology, with multiple loci already identified.1 Although the publication of a susceptibility locus is an important milestone in any disease, it represents only the opening act because the identity of the responsible gene within a locus is not always obvious. Without this knowledge, it becomes difficult (if not impossible) to establish a functional connection between genetic variation and the underlying pathobiology. Not surprisingly, this circumstance is a major challenge now faced by the entire genomics field. To bridge this gap, a multipronged approach has been adopted to delineate the effect of genetic variation on the expression of neighboring genes (known as expression quantitative trait loci mapping2) and to quantify the effects of epigenetic phenomena in regulating gene transcription. The term epigenetics covers a gamut of mechanisms such as DNA methylation, chromatin remodeling, gene expression regulation by microRNA, histone modification, and others.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

2 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles

Care at the Close of Life: Evidence and Experience
Alzheimer Disease: "It's OK, Mama, If You Want to Go, It's OK"

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Supplemental Content