Accepted for Publication: May 5, 2014.
Published Online: October 27, 2014. doi:10.1001/jamaneurol.2014.1482.
Study concept and design: Kantarci.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Kantarci.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Schwarz, Przybelski, Lesnick.
Obtained funding: Kantarci, Petersen, Jack.
Administrative, technical, or material support: Kantarci, Reid, Zuk, Senjem, Gunter, Lowe, Machulda, Petersen, Jack.
Study supervision: Kantarci, Jack.
Conflict of Interest Disclosures: Dr Kantarci serves on the data safety monitoring board for Pfizer Inc, Jannsen Alzheimer’s Immunotherapy, and Takeda Global Research & Development Center Inc, and she receives funding from the National Institutes of Health (NIH) (grants R01AG040042, principal investigator; R21 NS066147, principal investigator); Mayo Clinic Alzheimer’s Disease Research Center/Project 1 P50 AG16574/P1, principal investigator; P50 AG44170/Project 2, principal investigator, and R01 AG11378, coinvestigator. Dr Lowe is a consultant for Bayer Schering Pharma and receives research support from GE Healthcare, Siemens Molecular Imaging, AVID Radiopharmaceuticals, the NIH, the Elsie and Marvin Dekelboum Family Foundation, the MN Partnership for Biotechnology and Medical Genomics, and the Leukemia & Lymphoma Society. Dr Knopman serves as an associate editor for Neurology, serves on a data safety monitoring board for Lilly Pharmaceuticals, is an investigator in a clinical trial sponsored by Janssen Pharmaceuticals, and receives research support from the NIH (grants R01-AG11378 [coinvestigator], P50 AG16574 [coinvestigator], U01 AG 06786 [coinvestigator], AG 29550 [coinvestigator], AG32306 [coinvestigator], and U01 96917 [coinvestigator]). Dr Petersen serves on scientific advisory boards for Elan Pharmaceuticals, Wyeth Pharmaceuticals, and GE Healthcare; receives royalties from publishing Mild Cognitive Impairment (Oxford University Press, 2003); and receives research support from the NIH (grants P50-AG16574 [principal investigator], U01-AG06786 [principal investigator], R01-AG11378 [principal investigator], and U01-24904 [principal investigator]). Dr Jack has provided consulting services for Janssen Research & Development, LLC. He receives research funding from the NIH (grants R01-AG011378, U01-HL096917, U01-AG024904, RO1 AG041851, R01 AG37551, R01AG043392, and U01-AG06786) and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation. No other disclosures were reported.
Funding/Support: Design and conduct of the study was supported by the NIH (grants U01 AG06786, R01 AG040042, R01 AG11378, and C06 RR018898), the Elsie and Marvin Dekelboum Family Foundation, and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program. Collection, management, analysis, and interpretation of the data, as well as preparation, review, or approval of the manuscript, were supported by the NIH (grants U01 AG06786, R01 AG040042, and R01 AG11378).
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.