Accepted for Publication: July 25, 2014.
Published Online: October 20, 2014. doi:10.1001/jamaneurol.2014.2633.
Study concept and design: Langer-Gould, Tseng.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Langer-Gould, Tseng.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Langer-Gould, Qian.
Obtained funding: Langer-Gould, Tseng.
Administrative, technical, or material support: Langer-Gould, Tartof, Jacobsen.
Study supervision: Langer-Gould, Tseng.
Conflict of Interest Disclosures: Dr Langer-Gould is the site principal investigator for 2 industry-sponsored phase 3 clinical trials (Biogen Idec and Hoffman-LaRoche) and 1 industry-sponsored diagnostic assay observational study (Biogen Idec). She is also the principal investigator of an MS susceptibility study funded by the National Institutes of Health and a National MS Society research grant. Dr Chao has received research funding to perform studies related to HPV vaccine. Drs Tartof and Tseng have received research funding from Novartis for studies unrelated to this research. No other disclosures are reported.
Funding/Support: This research was supported by the Kaiser Permanente Direct Community Benefit Funds and the National Institute of Neurological Disorders and Stroke (grant 1R01NS075308; principal investigator, Dr Langer-Gould).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.