Accepted for Publication: June 4, 2014.
Published Online: October 13, 2014. doi:10.1001/jamaneurol.2014.1954.
Study concept and design: Russell, Barret, Jennings, Tamagnan, Thomae, Alagille, Morley, Papin, Papapetropoulos, Waterhouse, Seibyl, Marek.
Acquisition, analysis, or interpretation of data: Russell, Barret, Jennings, Friedman, Tamagnan, Thomae, Alagille, Morley, Papin, Seibyl, Marek.
Drafting of the manuscript: Russell, Marek.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Russell.
Obtained funding: Marek.
Administrative, technical, or material support: Barret, Jennings, Friedman, Thomae, Morley, Waterhouse, Seibyl.
Study supervision: Jennings, Tamagnan, Seibyl, Marek.
Conflict of Interest Disclosures: Dr Russell is an employee of Molecular NeuroImaging, LLC, and has served as a consultant for GE Healthcare and Teva Neuroscience. Dr Friedman lectures for GE Healthcare, Teva Neuroscience, and UCB; consults for Addex, Auspex, Lundbeck, Pfizer Inc, Roche, Teva Neuroscience, and UCB; has received funding for research from Avid, EMD Serono, the National Institutes of Health, Schering-Plough, and Teva Neuroscience; and receives royalties from Demos Press. Drs Barret, Jennings, Tamagnan, Alagille, Morley, and Papin are employees of Molecular NeuroImaging, LLC. Drs Papapetropoulos and Waterhouse are employees of Pfizer, Inc. Dr Seibyl has an equity interest in Molecular NeuroImaging, LLC, and serves as a consultant to GE Healthcare, Navidea, and Piramal. Dr Marek has ownership in Molecular NeuroImaging, LLC, and has served as a consultant for Bristol-Myers Squibb, Eli Lilly, GE Healthcare, Merck, NeuroPhage Pharmaceuticals, nLife Therapeutics, Pfizer, Piramal, Prothena, and Roche.
Funding/Support:Pfizer, Inc, provided partial funding for the study.
Role of the Funder/Sponsor: Pfizer, Inc, had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation of the manuscript; and decision to submit the manuscript for publication. Pfizer, Inc, reviewed the manuscript for proprietary information prior to the decision to submit the manuscript for publication. No changes in the manuscript resulted from this review.
Additional Contributions: Pfizer, Inc, provided scientific assistance.