Accepted for Publication: May 15, 2014.
Published Online: October 13, 2014. doi:10.1001/jamaneurol.2014.1663.
Study concept and design: Barral, Cosentino, Christensen, Newman, Mayeux.
Acquisition, analysis, or interpretation of data: Barral, Cosentino, Christensen, Perls, Province, Mayeux.
Drafting of the manuscript: Barral, Mayeux.
Critical revision of the manuscript for important intellectual content: Cosentino, Christensen, Newman, Perls, Province, Mayeux.
Statistical analysis: Barral.
Obtained funding: Newman, Perls, Province, Mayeux.
Administrative, technical, or material support: Newman, Perls, Mayeux.
Study supervision: Cosentino, Perls, Province, Mayeux.
Conflict of Interest Disclosures: None reported.
Funding/Support: The Long Life Family Study was sponsored by the National Institute on Aging ([NIA] cooperative agreements U01-AG023712, U01-AG23744, U01-AG023746, U01-AG023749, and U01-AG023755). The Danish 1905 cohort is funded by National Institutes of Health/NIA grant P01 AG08761. The Danish Aging Research Center is funded by the Velux Foundation.
Role of the Sponsor: Data collection, interpretation of the data, preparation of the manuscript, and decision to submit the manuscript for publication were performed by the National Institute on Aging Late-Onset Alzheimer Disease (grants U24-AG026395 and R01-4 AG041797); data collection was performed by the Alzheimer Disease 5 Neuroimaging Initiative (grant U01 AG024904), Alzheimer Disease Genetic Consortium (grants U01-AG03284, U01-AG016976, and U24-AG21886), and Washington Heights Aging Project (grants P01-AG007232 and R01-AG037212).
The Long Life Family Study Investigators:University of Southern Denmark, Odense: Kaare Christensen, MD, PhD, Lene Christiansen, PhD, Claus Ekstron, PhD, Quhua Tan, MD, PhD, and Birgit Debrabent, MSc; Columbia University, New York, New York: Richard Mayeux, MD, MSc, Sandra Barral, PhD, Nicole Schupf, PhD, Larry Honing, MD, PhD, Stephanie Cosentino, PhD, Rosann Costa, MA, and Joseph H. Lee, PhD; University of Minnesota, Minneapolis: Bharat Thyagarajan, MD; Pittsburgh University, Pittsburgh, Pennsylvania: Anne B. Newman, PhD, John Eckfeldt, MD, PhD, Candy Kammerer, PhD, Ryan Minster, PhD, Christina Wassel, PhD, Jeremy Walston, MD, and Joseph Zmuda, PhD; Washington University School of Medicine, St Louis, Missouri: Michael A. Province, PhD, Ping An, MD, Warwick Daw, PhD, Haley Abel, MA, PhD, Mary Feitosa, PhD, Aldi Kraja, DSc, PhD, Mary Wojczynski, PhD, and Qunyuan Zhang, PhD; Boston University, Boston, Massachusetts: Thomas T. Perls, MD, Harold Bae, PhD, Fungui Sun, PhD, Paola Sebastiani, PhD, and Stacy Andersen, PhD; Duke University, Durham, North Carolina: Anatoliy I. Yashin, PhD, Alexander Kulminski, PhD, Eric Stallard, BS, Svetlana Ukraintseva, PhD, and Konstantin Arbeev, PhD.