Accepted for Publication: July 16, 2014.
Published Online: October 6, 2014. doi:10.1001/jamaneurol.2014.2482.
Study concept and design: Tanzi, Koo, Ringman, Goldstein, Wagner, Yuan.
Acquisition, analysis, or interpretation of data: Liu, Waltz, Woodruff, Ouyang, Israel, Herrera, Sarsoza, Goldstein, Wagner, Yuan.
Drafting of the manuscript: Goldstein, Yuan.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Liu, Waltz, Yuan.
Obtained funding: Goldstein, Wagner, Yuan.
Administrative, technical, or material support: Ouyang, Israel, Herrera, Ringman, Goldstein.
Study supervision: Tanzi, Koo, Goldstein, Wagner, Yuan.
Conflict of Interest Disclosures: Drs Tanzi and Wagner are shareholders and cofounders of a privately held company (Neurogenetic Pharmaceuticals Inc) that holds rights to a γ-secretase modulator currently in preclinical development. No other disclosures were reported.
Funding/Support: This work was funded by National Institutes of Health grants U01-AG10483, U01-NS074501 (Dr Wagner), P50 AG005131-26 (Alzheimer’s Disease Research Centers pilot grant to Dr Yuan), and P50-AG016750 (Dr Rungman); California Institute of Regenerative Medicine Comprehensive grant RC1-00116 (Dr Goldstein); Cure Alzheimer’s Fund (Drs Tanzi and Wagner); and California Institute of Regenerative Medicine clinical training fellowship (Dr Yuan) and predoctoral fellowship (Dr Israel).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the volunteers who donated skin tissues; the University of California, San Diego, Alzheimer’s Disease Research Center for patient referral (AGO 5131); and Paul Aisen, MD (University of California, San Diego), for critical reading of the manuscript. He is funded by National Institutes of Health grant U01-AG10483.