Accepted for Publication: May 5, 2014.
Published Online: September 29, 2014. doi:10.1001/jamaneurol.2014.1472.
Study concept and design: Ireland, Davis, Monson.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Ireland, Monson.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Ireland, Monson.
Obtained funding: Monson.
Administrative, technical, or material support: Guzman, O’Brien, Hughes, Flores, Remington, Frohman.
Study supervision: Greenberg, Frohman, Davis, Monson.
Conflict of Interest Disclosures: Dr Greenberg has received honoraria or consulting fees from Amplimmune, Chugai, DioGenix, and Novartis. He has received grant support from Acorda Therapeutics, Biogen Idec, the Guthy Jackson Charitable Foundation, the National Institutes of Health, and Patients Centered Outcomes Research Institute. He has equity in Amplimmune and DioGenix. Dr Flores has participated in speaker programs for Biogen Idec and Teva Neuroscience. Ms Remington is a consultant for Biogen Idec, Genzyme, and Teva Neuroscience. Dr Frohman has received lecture and consulting fees from Acorda, Genzyme, Novartis, and Teva. Dr Monson receives grant funding from DioGenix, MedImmune Inc, and Teva Neuroscience. No other disclosures were reported.
Funding/Support: This work was supported by grant RG 4944 from Teva Neuroscience, the National MS Society, and the National Institutes of Health through National Research Service Award 5 T32 AI005284-34 from the National Institutes of Allergy and Infectious Disease.
Role of the Funder/Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation or approval of the manuscript; and decision to submit the manuscript for publication. Teva Neuroscience reviewed the manuscript prior to submission.
Additional Contributions: We thank the patients who participated in this study. Angela Mobley, BS, Christina Nguyen, BS, and Aina Iversen, BS (The University of Texas Southwestern Medical Center flow cytometry core), provided technical support. No financial compensation was given for their services.