Study concept and design: Pakpoor, Giovannoni, M. J. Goldacre.
Acquisition, analysis, or interpretation of data: Pakpoor, R. Goldacre, Disanto, M. J. Goldacre.
Drafting of the manuscript: Pakpoor, Giovannoni.
Critical revision of the manuscript for important intellectual content: R.Goldacre, Disanto, M. J. Goldacre.
Statistical analysis: R.Goldacre, M. J. Goldacre.
Obtained funding: M. J. Goldacre.
Study supervision: Giovannoni, M. J. Goldacre.
Conflict of Interest Disclosures: Dr Giovannoni serves on scientific advisory boards for Merck Serono, Biogen Idec, and Vertex Pharmaceuticals; has served on the editorial board of Multiple Sclerosis; and has received speaker honoraria from Bayer Schering Pharma, Merck Serono, Biogen Idec, Pfizer Inc, Teva Pharmaceutical Industries Ltd, sanofi-aventis, Vertex Pharmaceuticals, Genzyme Corp, Ironwood, and Novartis. Dr Giovannoni has also served as a consultant for Bayer Schering Pharma, Biogen Idec, GlaxoSmithKline, Merck Serono, Protein Discovery Laboratories, Teva Pharmaceutical Industries Ltd, sanofi-aventis, UCB, Vertex Pharmaceuticals, GW Pharma, Novartis, and FivePrime; serves on the speakers bureau for Merck Serono; and has received research support from Bayer Schering Pharma, Biogen Idec, Merck Serono, Novartis, UCB, Merz Pharmaceuticals LLC, Teva Pharmaceutical Industries Ltd, sanofi-aventis, GW Pharma, and Ironwood. No other disclosures were reported.
Funding/Support: The building of the linked datasets and the development of the analytical software used to study disease associations were funded by the UK National Institute for Health Research.
Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The views expressed in this article do not necessarily reflect those of the funding body.