Accepted for Publication: May 5, 2014.
Published Online: September 8, 2014. doi:10.1001/jamaneurol.2014.1491.
Study concept and design: Naj, Haines, Mayeux, Farrer, Schellenberg, Pericak-Vance.
Acquisition, analysis, or interpretation of data: Naj, Jun, Reitz, Kunkle, Perry, Park, Beecham, Rajbhandary, Hamilton-Nelson, Wang, Kramer, Ertekin-Taner, Hardy, Graff-Radford, Green, Larson, St. George-Hyslop, Buxbaum, Evans, Schneider, Kamboh, Saykin, Reiman, De Jager, Bennett, Morris, Montine, Goate, Blacker, Tsuang, Hakonarson, Kukull, Foroud, Haines, Mayeux, Farrer, Schellenberg, Pericak-Vance, Albert, Albin, Apostolova, Arnold, Barber, Barnes, Beach, Becker, Beekly, Bigio, Bowen, Boxer, Burke, Cairns, Cantwell, Cao, Carlson, Carney, Carrasquillo, Carrol, Chui, Clark, Corneveaux, Cribbs, Crocco, DeCarli, DeKosky, Dick, Dickson, Duara, Faber, Fallon, Farlow, Ferris, Frosch, Galasko, Ganguli, Gearing, Geschwind, Ghetti, Gilbert, Glass, Growdon, Hamilton, Harrell, Head, Honig, Hulette, Hyman, Jicha, Jin, Karydas, Kaye, Kim, Koo, Kowall, Kramer, LaFerla, Lah, Leverenz, Levey, Li, Lieberman, Lin, Lopez, Lyketsos, Mack, Martiniuk, Mash, Masliah, McCormick, McCurry, McDavid, McKee, Mesulam, B. L. Miller, C. A. Miller, J. W. Miller, Murrell, Olichney, Pankratz, Parisi, Paulson, Peskind, Petersen, Pierce, Poon, Potter, Quinn, Raj, Raskind, Reisberg, Ringman, Roberson, Rosen, Rosenberg, Sano, Schneider, Seeley, Smith, Sonnen, Spina, Stern, Tanzi, Thornton-Wells, Trojanowski, Troncoso, Valladares, Van Deerlin, Van Eldik, Vardarajan, Vinters, Vonsattel, Weintraub, Welsh-Bohmer, Williamson, Wishnek, Woltjer, Wright, Younkin, C-E. Yu, L. Yu.
Drafting of the manuscript: Naj, Pericak-Vance.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Naj, Kunkle, Perry, Park, Rajbhandary, Hamilton-Nelson, Pericak-Vance.
Obtained funding: Jarvik, Larson, St. George-Hyslop, Kamboh, Reiman, Bennett, Hakonarson, Haines, Farrer, Schellenberg, Pericak-Vance, Barnes, Beach, Leverenz.
Administrative, technical, or material support: Wang, Kauwe, Haines, Schellenberg, Geschwind.
Study supervision: Wang, Haines, Mayeux, Farrer, Schellenberg, Pericak-Vance.
Conflict of Interest Disclosures: Dr Bird reported receiving licensing fees from and serving on the speaker’s bureau of Athena Diagnostics, Inc. Dr Goate reported receiving research funding from AstraZeneca, Pfizer, and Genentech and receiving remuneration for giving talks at Pfizer and Genentech. Dr Petersen reported being Chair, Data Monitoring Committee, at Pfizer, Chair, Data Monitoring Committee, at Janssen Alzheimer Immunotherapy, a Consultant at GE Healthcare, and a Consultant at Roche. No other disclosures were reported.
Funding/Support: The National Institute on Aging supported this work through the following grants: U01 AG032984 and RC2 AG036528 (Alzheimer Disease Genetics Consortium); U01 AG016976 (National Alzheimer’s Coordinating Center); U24 AG021886 (National Cell Repository for Alzheimer Disease); U24 AG026395, R01AG041797, and U24 AG026390 (National Institute on Aging–Late-Onset Alzheimer Disease); P30 AG019610 (Banner Sun Health Research Institute); P30 AG013846, U01 AG10483, R01 CA129769, R01 MH080295, R01 AG017173, R01 AG025259, and R01AG33193 (Boston University); P50 AG008702 and R37 AG015473 (Columbia University); P30 AG028377 and AG05128 (Duke University); AG025688 (Emory University); UO1 AG06781 and UO1 HG004610 (Group Health Research Institute); P30 AG10133 (Indiana University); P50 AG005146 and R01 AG020688 (The Johns Hopkins University); P50 AG005134 (Massachusetts General Hospital); P50 AG016574 (Mayo Clinic); P50 AG005138 and P01 AG002219 (Mount Sinai School of Medicine); P30 AG08051, MO1RR00096, UL1 RR029893, 5R01AG012101, 5R01AG022374, 5R01AG013616, 1RC2AG036502, and 1R01AG035137 (New York University); P30 AG013854 (Northwestern University); P30 AG008017 and R01 AG026916 (Oregon Health & Science University); P30 AG010161, R01 AG019085, R01 AG15819, R01 AG17917, and R01 AG30146 (Rush University); R01 NS059873 (Translational Genomics Research Institute); P50 AG016582 and UL1RR02777 (University of Alabama at Birmingham); R01 AG031581 (University of Arizona); P30 AG010129 (University of California, Davis); P50 AG016573, P50 AG016575, P50 AG016576, and P50 AG016577 (University of California, Irvine); P50 AG016570 (University of California, Los Angeles); P50 AG005131 (University of California, San Diego); P50 AG023501 and P01 AG019724 (University of California, San Francisco); P30 AG028383 and AG05144 (University of Kentucky); R01 AG027944, AG010491, AG027944, AG021547, and AG019757 (University of Miami); P50 AG008671 (University of Michigan); P30 AG010124 (University of Pennsylvania); P50 AG005133, AG030653, and AG041718 (University of Pittsburgh); P50 AG005142 (University of Southern California); P30 AG012300 (University of Texas Southwestern); P50 AG005136 (University of Washington); R01 AG019085 (Vanderbilt University); and P50 AG005681 and P01 AG03991 (Washington University in St Louis). The Kathleen Price Bryan Brain Bank at Duke University Medical Center is funded by grant NS39764 from the National Institute of Neurological Disorders and Stroke, by grant MH60451 from the National Institute of Mental Health, and by GlaxoSmithKline. Genotyping of the Translational Genomics Research Institute 2 cohort was supported by Kronos Science. The Translational Genomics Research Institute series was also funded by grant AG034504 from the National Institute on Aging (Dr Myers) and by the Alzheimer’s Foundation, Johnnie B. Byrd Sr Alzheimer’s Institute, Medical Research Council, and State of Arizona and includes samples from the following sites: Newcastle Brain Tissue Resource (funding via the Medical Research Council, local National Health Service trusts, and Newcastle University), Medical Research Council London Brain Bank for Neurodegenerative Diseases (funding via the Medical Research Council), South West Dementia Brain Bank (funding via numerous sources, including the Higher Education Funding Council for England, Alzheimer’s Research Trust, and BRACE [Bristol Research Into Alzheimer’s and Care of the Elderly], as well as North Bristol National Health Service Trust Research and Innovation Department and Dementias and Neurodegeneration), Netherlands Brain Bank (funding via numerous sources, including Stichting MS Research, Brain Net Europe, Hersenstichting Nederland Breinbrekend Werk, International Parkinson Fonds, and Internationale Stiching Alzheimer Onderzoek), Institut de Neuropatologia, Servei Anatomia Patologica, and Universitat de Barcelona. Funding for the Alzheimer’s Disease Neuroimaging Initiative is through the Northern California Institute for Research and Education by grants from Abbott, AstraZeneca, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson & Johnson, Eli Lilly and Company, Medpace, Inc, Merck and Co, Inc, Novartis AG, Pfizer, F. Hoffman–La Roche, Schering-Plough, Synarc, Inc, Alzheimer’s Association, Alzheimer’s Drug Discovery Foundation, and The Dana Foundation, as well as by the National Institute of Biomedical Imaging and Bioengineering and by grants U01 AG024904, RC2 AG036535, and K01 AG030514 from the National Institute on Aging. Support was also by grants IIRG-05-14147 and IIRG-08-89720 from the Alzheimer’s Association (Dr Pericak-Vance) and by the Biomedical Laboratory Research Program, Office of Research and Development, US Department of Veterans Affairs Administration. Dr St. George-Hyslop is supported by the Wellcome Trust, Howard Hughes Medical Institute, and Canadian Institute of Health Research.
Role of Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: D. Stephen Snyder, PhD, and Marilyn Miller, PhD, from the National Institute on Aging contributed to this work as ex officio Alzheimer Disease Genetics Consortium members.
Correction: This article was corrected on November 10, 2014, to fix an error in the byline.