Accepted for Publication: May 10, 2014.
Published Online: September 8, 2014. doi:10.1001/jamaneurol.2014.1620.
Study concept and design: George, Leite, Palace, Elston.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: George,Palace.
Critical revision of the manuscript for important intellectual content: All authors.
Study supervision: Leite, Palace, Elston.
Conflict of Interest Disclosures: Dr Leite is involved in AQP4 and myelin-oligodendrocyte glycoprotein antibody testing; is supported by the National Health Service National Specialised Commissioning Group for Neuromyelitis Optica and by the National Institute for Health Research Oxford Biomedical Research Centre; and has received speaking honoraria from Biogen Idec and travel grants from Novartis. Dr Kitley has received support for scientific meetings from Biogen Idec, Novartis, and Teva; speaker honoraria from Novartis and Terumo BCT; and was supported by the National Health Service National Specialised Commissioning Group for Neuromyelitis Optica. Dr Donati has received sponsorship for educational meetings that he organizes and support for attending scientific meetings from Gilead, Sanofi Pasteur MSD, Janssen, and Hologic. Dr Palace is partly funded by highly specialized services to run a national congenital myasthenia service and a national neuromyelitis optica service. She has received support for scientific meetings and honoraria for advisory work from Merck-Serono, Biogen Idec, Novartis, Teva, Chugai Pharma, and Bayer Schering, as well as unrestricted grants from Merck Serono, Novartis, Biogen Idec, and Bayer Schering. Her hospital trust receives funds for her role as a clinical lead for the UK Department of Health Risk Sharing Scheme, and she has received grants from the Multiple Sclerosis Society and Guthy-Jackson Charitable Foundation for unrelated research studies. No other disclosures were reported.
Additional Contributions: We are grateful to both of our patients for providing written informed consent to publish this report.