Accepted for Publication: April 28, 2014.
Published Online: August 25, 2014. doi:10.1001/jamaneurol.2014.1358.
Study concept and design: Palmqvist, Blennow, Wollmer, Hansson.
Acquisition, analysis, or interpretation of data: Palmqvist, Zetterberg, Vestberg, Andreasson, Brooks, Owenius, Hägerström, Wollmer, Minthon, Hansson.
Drafting of the manuscript: Palmqvist, Hansson.
Critical revision of the manuscript for important intellectual content: Palmqvist, Zetterberg, Blennow, Vestberg, Andreasson, Brooks, Owenius, Hägerström, Wollmer, Minthon.
Statistical analysis: Palmqvist, Andreasson.
Obtained funding: Hansson.
Administrative, technical, or material support: Palmqvist, Zetterberg, Blennow, Vestberg, Andreasson, Owenius, Hägerström, Wollmer, Minthon, Hansson.
Study supervision: Palmqvist, Blennow, Brooks, Wollmer, Hansson.
Conflict of Interest Disclosures: Dr Blennow has served at advisory boards for Koyowa Kirin Pharma, Eli Lilly, Pfizer, and Roche. Dr Brooks is a consultant to GE Healthcare. Dr Owenius is an employee of GE Healthcare. No other disclosures were reported.
Funding/Support: This study was supported by the European Research Council, the Swedish Research Council, the Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson’s disease) at Lund University, the Crafoord Foundation, the Swedish Brain Foundation, the Johan and Jakob Söderberg’s Foundation, and the Swedish federal government under the ALF agreement Swedish Brain Power. Doses of 18F-flutemetamol injection were sponsored by GE Healthcare.
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Jimmy Lätt, PhD (Department of Medical Radiation Physics, Lund University, Lund, Sweden), and Olof Lindberg, PhD (Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden), for the FreeSurfer analysis of hippocampal volumes. They did not receive compensation from a funder for their work.