Accepted for Publication: April 17, 2014.
Published Online: August 18, 2014. doi:10.1001/jamaneurol.2014.1234.
Study concept and design: Naasan, Irani, Geschwind, Gelfand.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Naasan, Irani, Geschwind, Gelfand.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Bettcher, Gelfand.
Obtained funding: Geschwind, Gelfand.
Administrative, technical, or material support: Naasan, Geschwind.
Study supervision: Irani, Geschwind, Gelfand.
Conflict of Interest Disclosures: Dr Irani is a coapplicant on a patent for the discovery of VGKC-complex antigenic targets (including LGI1) and receives royalties. Dr Geschwind is a consultant for Lundbeck Inc, MedaCorp, and the Council of Advisors and Neurophage and has received research funding from the Tau Consortium and CurePSP. Dr Gelfand has received compensation for medical legal consulting work related to central nervous system inflammatory demyelinating disease. No other disclosures are reported.
Funding/Support: Research was supported by grant KL2TR000143 from the National Center for Advancing Translational Sciences of the National Institutes of Health, grants R01-AG031189 and R01-AG021601 from the National Institute on Aging of the National Institutes of Health, a commission from the UK-US Fulbright Program, the Multiple Sclerosis Society, and Epilepsy Research United Kingdom.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The contents of this study are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
Additional Contributions: We thank Kendra Bechtel, BA, University of California, San Francisco, Sven Forner, BA, University of California, San Francisco, and Aya Abounasar, BS, University of California, San Francisco, for research coordination and our patients and their families. Ms Bechtel and Mr Forner are employees at University of California, San Francisco, paid by grants received from the National Institutes of Health and Ms Abounasar is an employee at University of California, San Francisco.
Correction: This article was corrected on September 10, 2014, to fix typographical errors in the text.