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Comment & Response |

Blood Test for Variant Creutzfeldt-Jakob Disease—Reply

Graham S. Jackson, PhD1; Jesse Burk-Rafel, MSc1,2; Simon Mead, BM BCh1,3; John Collinge, FRS1,3
[+] Author Affiliations
1MRC Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, England
2University of Michigan Medical School, Ann Arbor
3National Prion Clinic, National Hospital for Neurology and Neurosurgery, London, England
JAMA Neurol. 2014;71(8):1054-1055. doi:10.1001/jamaneurol.2014.1539.
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In Reply We are in complete agreement with Bennett’s statement that a key consideration for a vCJD screening test of blood donations is specificity. Our study was designed to refine the confidence intervals of our previous estimate of 100%1 and was conducted with reference to the Common Technical Specification of the European Commission for acceptance of a vCJD blood test as fit for purpose, requiring 99.5% specificity in a cohort of 5000 samples.2


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August 1, 2014
Peter Bennett, PhD
1Department of Health, London, England
JAMA Neurol. 2014;71(8):1054. doi:10.1001/jamaneurol.2014.944.
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