Accepted for Publication: May 13, 2014.
Published Online: August 4, 2014. doi:10.1001/jamaneurol.2014.1646.
Study concept and design: Gottesman, Schneider, Bandeen-Roche, Coresh, Sharrett, Mosley.
Acquisition, analysis, or interpretation of data: Gottesman, Schneider, Albert, Alonso, Bandeen-Roche, Coker, Knopman, Power, Rawlings, Sharrett, Wruck, Mosley.
Drafting of the manuscript: Gottesman.
Critical revision of the manuscript for important intellectual content: Schneider, Albert, Alonso, Bandeen-Roche, Coker, Coresh, Knopman, Power, Rawlings, Sharrett, Wruck, Mosley.
Statistical analysis: Gottesman, Schneider, Bandeen-Roche, Power, Rawlings, Sharrett, Wruck.
Obtained funding: Coker, Coresh, Mosley.
Administrative, technical, or material support: Coker.
Study supervision: Bandeen-Roche.
Conflict of Interest Disclosures: Dr Knopman serves as deputy editor for Neurology; serves on a data safety monitoring board for Lundbeck Pharmaceuticals and for the Dominantly Inherited Alzheimer’s Disease Treatment Unit; served on a data safety monitoring board for Lilly Pharmaceuticals (completed 2012); served as a consultant to Tau RX (completed 2012); was an investigator in clinical trials sponsored by Baxter and Elan Pharmaceuticals in the past 2 years (completed 2012); and receives research support from the National Institutes of Health (NIH). No other disclosures were reported.
Funding/Support: The ARIC Study is part of a collaborative study supported by contracts HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C from the National Heart, Lung, and Blood Institute (NHLBI). Neurocognitive data collection was supported by contracts U01 HL096812, HL096814, HL096899, HL 096902, and HL 096917 from the NHLBI and the National Institute of Neurological Disorders and Stroke, and previous magnetic resonance imaging examinations of the brain were supported by contract R01-HL70825 from the NHLBI. This study was also supported by contract T32HL007024 from the NHLBI, NIH (Dr Schneider and Ms Rawlings) and by contract T32AG027668 from the National Institute on Aging, NIH (Dr Power).
Role of Sponsor: The funding sources had no role in the design and conduct of the study other than membership by program officers on the study steering committee; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Information: Members of the ARIC Neurocognitive Study (NCS) Steering Committee include Thomas H. Mosley, PhD (chair), Josef Coresh, MD, PhD (cochair), Marilyn Albert, PhD, Alvaro Alonso, MD, PhD, Christie Ballantyne, MD, Eric Boerwinkle, PhD, David Couper, PhD, Gerardo Heiss, MD, PhD, Clifford Jack, MD, Barbara Klein, MD, MPH, Ronald Klein, MD, MPH, David Knopman, MD, Natalie Kurinij, PhD (National Eye Institute project officer), Claudia Moy, PhD (National Institute of Neurological and Communicative Diseases and Stroke project officer), and Jacqueline Wright, PhD (NHLBI project officer). Ex officio members include Laura Coker, PhD, Aaron Folsom, MD, MPH, Rebecca F. Gottesman, MD, PhD, A. Richey Sharrett, MD, DrPH, Lynne Wagenknecht, DrPH, and Lisa M. Wruck, PhD. Members of the ARIC-NCS Data Analysis Committee (drafted and critically revised all analysis plans) include A. Richey Sharrett, MD, DrPH (chair), Karen Bandeen-Roche, PhD (senior statistician), Andrea L. C. Schneider, PhD, Josef Coresh, MD, PhD, Jennifer Deal, PhD, Rebecca F. Gottesman, MD, PhD, Michael Griswold, PhD, Alden Gross, PhD, Thomas H. Mosley, PhD, Melinda C. Power, ScD, Andreea Rawlings, MS, Lisa M. Wruck, PhD, and Shoshana Ballew, PhD (epidemiologist coordinator). Members of the ARIC-NCS Neurocognitive Committee include Thomas H. Mosley, PhD (chair), Rebecca F. Gottesman, MD, PhD (cochair), Alvaro Alonso, MD, PhD, Laura Coker, PhD, David Couper, PhD, David Knopman, MD, Guy McKhann, MD, Ola Selnes, PhD, and A. Richey Sharrett, MD, DrPH.
Additional Contributions: We thank the staff and participants of the ARIC Study for their important contributions.