Accepted for Publication: June 10, 2014.
Published Online: July 28, 2014. doi:10.1001/jamaneurol.2014.1654.
Study concept and design: Thomas, Brier, Bateman, Snyder, Benzinger, Raichle, Holtzman, Mayeux, Masters, Hornbeck, Schultz, Marcus, Ances.
Acquisition, analysis, or interpretation of data: Thomas, Brier, Benzinger, Xiong, Sperling, Ghetti, Ringman, Salloway, McDade, Rossor, Ourselin, Schofield, Martins, Weiner, Thompson, Fox, Koeppe, Jack, Mathis, Oliver, Blazey, Moulder, Buckles, Chhatwal, Goate, Fagan, Cairns, Morris, Ances.
Drafting of the manuscript: Thomas, Brier, Bateman, Snyder, Raichle, Oliver, Blazey, Hornbeck, Ances.
Critical revision of the manuscript for important intellectual content: Thomas, Bateman, Benzinger, Xiong, Sperling, Mayeux, Ghetti, Ringman, Salloway, McDade, Rossor, Ourselin, Schofield, Masters, Martins, Weiner, Thompson, Fox, Koeppe, Jack, Mathis, Moulder, Buckles, Chhatwal, Schultz, Goate, Fagan, Marcus, Ances.
Statistical analysis: Thomas, Brier, Bateman, Snyder, Xiong, Holtzman, Salloway, Ourselin, Blazey, Chhatwal, Cairns, Morris, Ances.
Obtained funding: Bateman, Benzinger, Ghetti, Ringman, Masters, Martins, Weiner, Moulder, Buckles, Goate, Morris, Ances.
Administrative, technical, or material support: Thomas, Snyder, Benzinger, Raichle, Ghetti, Rossor, Schofield, Thompson, Fox, Koeppe, Jack, Oliver, Moulder, Buckles, Fagan, Cairns, Marcus, Ances.
Study supervision: Thomas, Bateman, Benzinger, Holtzman, Ourselin, Martins, Goat, Morris, Ances.
Conflict of Interest Disclosures: Dr Bateman receives funding from Fidelity Nonprofit Management Foundation, is a board member for EvVivo Scientific Advisory Board, and consults with C2N Diagnostics, Eisai Scientific Advisory Panel, Medtronics Scientific Advisory Panel, and Novartis; he is also funded or pending funding by the National Institutes of Health, Alzheimer’s Association, Glenn Foundation for Medical Research, AstraZeneca LP, Merck & Company Inc, Eli Lilly and Co, Pharma Consortium (Biogen Idec, Elan Pharmaceuticals Inc, Eli Lilly and Co, Hoffman-La Roche Inc, Genentech Inc, Janssen Alzheimer Immunotherapy, Mithridion Inc, Novartis Pharma AG, Pfizer Biotherapeutics R and D, and sanofi-aventis), The Ruth K Broad Biomedical Research Foundation, Elan and AstraZeneca, Washington University, and C2N Diagnostics. Dr Benzinger has received research funding from Avid Radiopharmaceuticals, a wholly owned subsidiary of Eli Lilly. Dr Fagan receives funding from the National Institutes of Health and is a member of the scientific advisory boards for IBL International and Roche. Dr Fox has received payment for consultancy or for conducting studies from Avid, Bristol-Myers Squibb, Elan Pharmaceuticals, Eisai, Lilly Research Laboratories, GE Healthcare, IXICO, Janssen Alzheimer Immunotherapy, Johnson & Johnson, Janssen-Cilig, Lundbeck, Neurochem Inc, Novartis Pharma AG, Pfizer Inc, sanofi-aventis, and Wyeth Pharmaceuticals; he has a National Institute for Health Research Senior Investigator award and receives support from the Wolfson Foundation, National Institute for Health Research Biomedical Research Unit (Dementia) at University College London, the EPSRC, Alzheimer’s Research United Kingdom, and the NIA; and receives no personal compensation for the activities mentioned above. Dr Ghetti consults for Piramal Imaging. Dr Goate receives funding from AstraZeneca, Genentech, Pfizer, Tau Consortium, and the DIAN Pharmaceutical Consortium: Biogen Idec, Eisai Inc, Elan Pharmaceuticals Inc, Eli Lilly and Company, FORUM Pharmaceuticals, Hoffman-La Roche Inc, Genetech Inc, Janssen Alzheimer Immunotherapy, Mithridion Inc, Novartis Pharm AG, Pfizer Biotherapeutics Research & Development, sanofi-aventis; she also consults for Amgen and Cognition Therapeutics and received payments for lectures including service on speaker bureaus from Pfizer, AstraZeneca, and Genentech; she receives royalties for IP licensed to Taconic. Dr Holtzman receives research funding from the National Institutes of Health, AstraZeneca, C2N Diagnostics, Cure Alzheimer’s Fund, and Tau Consortium; he serves on the scientific advisory board of C2N Diagnostics and consults for Bristol-Myers Squibb, Eli Lilly, and Genentech; he holds US patents 7,892,845, 7,892,545, 7,771,722, 7,195,761, 7,015,044, and 6,465,195. Dr Jack has provided consulting services for Janssen Research & Development, LLC, and Eli Lilly; receives research support from the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation. Dr Marcus consults with Avid Radiopharmaceuticals and has stock options with Radiologics Inc; he receives travel, accommodations, and meeting expenses unrelated to activities listed from BlueArc Inc. Dr Masters has advisory roles with Prana Biotechnology and the Eli Lilly Company. Dr Morris has participated or is currently participating in clinical trials of antidementia drugs sponsored by Janssen Immunotherapy and Pfizer; has served as a consultant for Lilly USA; and receives research support from Eli Lilly/Avid Radiopharmaceuticals. Dr Ourselin receives funding from GE Healthcare, Siemens, and Mirada Medical. Dr Ringman has received compensation for serving on scientific advisory boards for Takeda Pharmaceuticals and StemCells, Inc and has received research support from Janssen, Pfizer, Accera, Bristol-Myers Squibb, and Wyeth Pharmaceuticals. Dr Salloway is a consultant for Janssen AI, AstraZeneca, Avid-Lilly, GE, Baxter, Pfizer, Athena, Bristol-Myers Squibb, Biogen, and Merck. Dr Schofield receives funding from the Australian National Health and Medical Research Council, Australian Research Council, and Beyondblue; he is a board member of Neuroscience Research Australia, the Neuroscience Research Australia Foundation, and the Health Science Alliance; is an employee of Neuroscience Research Australia; and has received speaker fees from Janssen Pharmaceuticals Australia. Dr Schultz has served on an advisory board for Janssen Pharmaceuticals. Dr Sperling consults for Pfizer, Janssen, Eisai, Roche, and Bristol-Myers Squibb and receives payment for lectures including service on speakers bureaus from Pfizer, Janssen, and Eli Lilly. Dr Weiner has served on the scientific advisory boards for Pfizer, BOLT International, Neurotrope Bioscience, and Eli Lilly; has provided consulting to Synarc, Pfizer, Janssen, KLJ Associates, Easton Associates, Harvard University, University of California, Los Angeles, Alzheimer’s Drug Discovery Foundation, Avid Radiopharmaceuticals, Clearview Healthcare Partners, Perceptive Informatics, Smartfish AS, Decision Resources, Inc, Araclon, Merck, Defined Health, and Genentech; has served on the editorial boards for Alzheimer’s & Dementia and MRI; received honoraria from Pfizer, Tohoku University, and Danone Trading, BV; and has received research support from Merck, Avid, the Veterans Administration, and the Department of Defense. The following entities have provided funding for travel: Pfizer, Paul Sabatier University, MCI Group France, Travel eDreams, Inc, Neuroscience School of Advanced Studies, Danone Trading, BV, CTAD Ant Congres, Kenes, Intl, ADRC, University of California, Los Angeles, University of California, San Diego, sanofi-aventis Groupe, University Center Hospital, Toulouse, Araclon, AC Immune, Eli Lilly, New York Academy of Sciences, the National Brain Research Center, and India for Johns Hopkins Medicine.
Funding/Support: This work was funded by grants U19-AG032438 from the National Institute on Aging; K23MH081786 and R21MH099979 from the National Institute of Mental Health; R01NR014449, R01NR012657, and R01NR012907 from the National Institute of Nursing Research; P30NS048056, P50 AG05681, P01 AG03991, and P01 AG026276 from the National Institute of Neurological Disorders and Stroke; and G0601846 from the Medical Research Council. The study was also supported by the National Institute for Health Research Queen Square Dementia Biomedical Research Unit and the Washington University in St Louis Alzheimer’s Disease Research Center Genetics Core. Dr Jack received grants R01-AG011378, U01-HL096917, U01-AG024904, RO1 AG041851, R01 AG37551, R01AG043392, and U01-AG06786 from the National Institutes of Health. Dr Morris received grants P50AG005681, P01AG003991, P01AG026276, and U19AG032438 from the National Institutes of Health. Dr Ourselin received grants EP/H046410/1, EP/J020990/1, and EP/K005278 from the Engineering and Physical Sciences Research Council; MR/J01107X/1 from the the Medical Research Council; and FP7-ICT-2011-9-601055 from the EUFP7 project at the National Institute for Health Research University College London Hospitals Biomedical Research Centre High Impact Initiative.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Information: The authors are members of the Dominantly Inherited Alzheimer Network. For more information, visit http://www.dian-info.org/#.