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Comment & Response |

Tau, S-100 Calcium-Binding Protein B, and Neuron-Specific Enolase as Biomarkers of Concussion

Jeffrey J. Bazarian, MD, MPH1; Kian Merchant-Borna, MPH1
[+] Author Affiliations
1Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York
JAMA Neurol. 2014;71(7):925-926. doi:10.1001/jamaneurol.2014.1082.
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To the Editor That the Quanterix platform was able to detect elevated levels of tau at subfentamole concentrations after sports-related concussion is indeed an exciting development in the article by Shahim and colleagues.1 However, the conclusion made by Shahim et al,1 and by the accompanying editorial,2 that S-100 calcium-binding protein B (S-100B) and neuron-specific enolase (NSE) lack use as diagnostic markers is flawed for several reasons.

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July 1, 2014
Pashtun Shahim, MD; Kaj Blennow, MD, PhD; Henrik Zetterberg, MD, PhD
1Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden
1Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden2Reta Lila Weston Laboratories, Department of Molecular Neuroscience, University College London Institute of Neurology, London, England
JAMA Neurol. 2014;71(7):926-927. doi:10.1001/jamaneurol.2014.1160.
June 1, 2014
Pashtun Shahim, MD; Yelverton Tegner, MD, PhD; David H. Wilson, PhD; Jeffrey Randall, PhD; Tobias Skillbäck, MD; David Pazooki, MD, PhD; Birgitta Kallberg, BSc; Kaj Blennow, MD, PhD; Henrik Zetterberg, MD, PhD
1Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden
2Division of Medical Sciences, Department of Health Sciences, Luleå University of Technology, Luleå, Sweden
3Quanterix Corp, Lexington, Massachusetts
4Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
5Clinical Chemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
1Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden6Reta Lila Weston Laboratories, Department of Molecular Neuroscience, Institute of Neurology, University College London, London, England
JAMA Neurol. 2014;71(6):684-692. doi:10.1001/jamaneurol.2014.367.
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