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Features of Neuromyelitis Optica Spectrum Disorders With Aquaporin-4 and Myelin-Oligodendrocyte Glycoprotein Antibodies

Jiguo Gao, MD1,2; Wei Pan, MD3; Hongliang Zhang, MD, PhD1
[+] Author Affiliations
1Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China
2Department of Neurology, The Second Part, The First Hospital of Jilin University, Changchun, China
3School of Public Health, Jilin University, Changchun, China
JAMA Neurol. 2014;71(7):923-924. doi:10.1001/jamaneurol.2014.764.
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To the Editor In their article, Kitley and colleagues1 characterized the features of patients with neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSDs) with myelin-oligodendrocyte glycoprotein antibodies (Abs) and compared them with patients with aquaporin-4 antibody (AQP4-Ab)–positive NMO/NMOSD. They found that patients with myelin-oligodendrocyte glycoprotein Abs who fulfilled the diagnostic criteria for NMO were different from those with AQP4-Abs in terms of sex preponderance, age distribution, and involvement of conus and deep gray matter structures on imaging, as well as outcomes.1


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July 1, 2014
Joanna Kitley, BMBS; Patrick Waters, PhD; Angela Vincent, FRS; Jacqueline Palace, DM
1Nuffield Department of Clinical Neurosciences, Oxford University Hospitals NHS Trust, University of Oxford, Oxford, England
JAMA Neurol. 2014;71(7):924. doi:10.1001/jamaneurol.2014.940.
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