Accepted for Publication: April 8, 2014.
Published Online: July 7, 2014. doi:10.1001/jamaneurol.2014.1065.
Study concept and design: Fu, Huang, Shi.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Fu, Hao, Sun, Shi.
Critical revision of the manuscript for important intellectual content: Fu, Zhang, Ren, Sun, Li, Yan, Huang, Yu, Shi.
Statistical analysis: Fu, Zhang, Ren, Li.
Obtained funding: Shi.
Administrative, technical, or material support: Yan, Yu, Shi.
Study supervision: Shi.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported in part by the National Basic Research Program of China (grant 2013CB966900), the National Science Foundation of China (grant 81230028), the National Key Clinical Specialty Construction Program of China, the US National Institutes of Health (grant R01AI083294), and the American Heart Association (grant 14GRNT18970031).
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank our patients for participating in this study. We also thank Peng Zhao, MD (Tianjin Medical University General Hospital), Song Wang, MD (Henry Ford Hospital), and Ying Xiao, MD (Tianjin Medical University General Hospital), for facilitating recruitment of the patients; Jieli Chen, MD, PhD, for providing advice; Wei Han, MD (Tianjin Medical University General Hospital), Minshu Li, PhD (Tianjin Medical University General Hospital), Weina Jin, PhD (Tianjin Medical University General Hospital), and Jinting Xiao, MD (Tianjin Medical University General Hospital), for assisting with technical support; and Phyllis Minick, MD (St Joseph’s Hospital and Medical Center), for providing editorial assistance. They did not receive compensation from a funding sponsor for their contributions.