Accepted for Publication: March 21, 2014.
Published Online: June 30, 2014. doi:10.1001/jamaneurol.2014.825.
Study concept and design: Alstadhaug, Croughs, Sereti, Rinaldo.
Acquisition, analysis, or interpretation of data: Alstadhaug, Henriksen, Leboeuf, Hirsch, Rinaldo.
Drafting of the manuscript: Alstadhaug, Sereti, Hirsch, Rinaldo.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Alstadhaug.
Administrative, technical, or material support: Alstadhaug, Croughs, Henriksen, Leboeuf, Hirsch, Rinaldo.
Study supervision: Croughs, Sereti, Hirsch, Rinaldo.
Conflict of Interest Disclosures: Dr Croughs reported being an employee and shareholder of Cytheris at the time rhIL-7 was given for compassionate use.
Funding/Support: Dr Sereti reported that her work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases.
Role of the Sponsor: The funding organization had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We are grateful to study nurse Anne Lise Amundsen, Department of Neurology, Nordland Hospital Trust, Bodø, Norway, for coordinating treatment of the patient, Kristin Smistad Myrmel, MD, Department of Pathology, University Hospital of North Norway, Tromsø, Norway, for providing microscopic pictures and histopathologic description of PML in the brain biopsy specimen, Piotr Kardas, MS, Division of Transplantation and Clinical Virology, Department of Biomedicine (Haus Petersplatz), University of Basel, Basel, Switzerland, for providing the JCV-like particles, Jacqueline Samarides, Division of Transplantation and Clinical Virology, Department of Biomedicine (Haus Petersplatz), University of Basel, Basel, Switzerland, for performing the enzyme-linked immunosorbent assay, and Axel Regeniter, MD, Diagnostic Laboratory, University Hospital Basel, Basel, Switzerland, for quantifying albumin and immunoglobulin in the CSF and serum samples. None of these contributors received extra compensation for their work.