Accepted for Publication: April 2, 2014.
Published Online: June 23, 2014. doi:10.1001/jamaneurol.2014.963.
Study concept and design: Vemuri, Lesnick, Geda, Jack.
Acquisition, analysis, or interpretation of data: Vemuri, Lesnick, Przybelski, Machulda, Knopman, Mielke, Roberts, Rocca, Petersen, Jack.
Drafting of the manuscript: Vemuri, Lesnick.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Lesnick, Przybelski, Rocca.
Obtained funding: Vemuri, Roberts, Jack.
Administrative, technical, or material support: Vemuri, Mielke, Jack.
Study supervision: Vemuri, Jack.
Conflict of Interest Disclosures: Dr Vemuri reported receiving research funding from the National Institute on Aging and the Alzheimer’s Association. Dr Knopman reported serving as deputy editor for Neurology, serving on a data safety monitoring board for Lilly Pharmaceuticals, serving as an investigator in clinical trials sponsored by Janssen Pharmaceuticals, and receiving research support from the National Institutes of Health. Dr Mielke reported serving as a consultant for Eli Lilly and receiving funding from the National Institute of Aging. Drs Rocca and Roberts reported receiving research funding from the National Institutes of Health. Dr Petersen reported receiving consulting fees from Roche Inc, Merck, and Genentech, receiving royalties from Oxford University Press, serving as chair of data monitoring committees for Pfizer Inc and Janssen Alzheimer Immunotherapy, and receiving research support from the National Institute on Aging. Dr Jack reported serving as a consultant for Siemens; receiving research funding from grants R01-AG011378, R01-AG041851, R01-AG037551, U01-HL096917, U01-AG032438, and U01-AG024904 from the National Institutes of Health; and receiving funding from the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation. No other disclosures were reported.
Funding/Support: This work was supported by grants K99/R00-AG37573, R01-AG011378, R01-AG041851, P50-AG16574, and U01-AG06786 from the National Institutes of Health, the Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Foundation, and grant C06-RR018898 from the National Institutes of Health for the Opus Building.
Role of the Sponsors: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.