Accepted for Publication: March 20, 2014.
Published Online: June 9, 2014. doi:10.1001/jamaneurol.2014.808.
Study concept and design: Margolis, Wang, Copher, Cavazos.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: All authors.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Margolis, Chu, Copher, Cavazos.
Obtained funding: Margolis, Wang.
Administrative, technical, or material support: Margolis, Wang.
Study supervision: Margolis, Wang.
Conflict of Interest Disclosures: Drs Margolis and Chu are employees of Truven Health Analytics, which was paid by Eisai Inc in connection with the research described in this article. Drs Wang and Copher are employees of Eisai Inc. No other disclosures were reported.
Funding/Support: This research was sponsored by Eisai Inc, Woodcliff Lake, New Jersey.
Role of the Sponsor: Eisai Inc had a role in the design and conduct of the study; analysis and interpretation of the data; preparation, review, and approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Editorial assistance was provided by Michele Shaw, PharmD, who was funded by Truven Health Analytics. We acknowledge the key contributions of Larry Radbill, MA (Truven Health Analytics), for his tireless work in defining, extracting, assembling, and analyzing the data. He did not receive funding from the study sponsor for his contributions.