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Comment & Response |

Medulloblastoma and Dizziness

Miguel Gelabert-González, MD, PhD1; Eduardo Arán-Echabe, MD1
[+] Author Affiliations
1Department of Surgery, University of Santiago de Compostela, Santiago de Compostela, Spain
JAMA Neurol. 2014;71(6):801. doi:10.1001/jamaneurol.2014.173.
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To the Editor We read with interest the article by Shu et al1 and we would like to make the following observations on the basis of our personal experience.

Medulloblastoma is a primitive neuroectodermal tumor and about 50% of these tumors occur in children aged younger than 5 years, whereas they are rare in adolescents and young adults. Medulloblastoma behaves differently in adults than in children and is identified as a different biological and clinical entity. It exhibits a higher proportion of desmoplastic histologic characteristics than childhood medulloblastoma and shows a higher incidence within the cerebellar hemispheres, thus featuring different proliferative and apoptotic indices and having a tendency for late relapse.2


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June 1, 2014
James Battiste, MD, PhD; Francy Shu, MD; Steven Vernino, MD, PhD
1Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Oklahoma City
2Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas
JAMA Neurol. 2014;71(6):801-802. doi:10.1001/jamaneurol.2014.522.
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