Accepted for Publication: April 14, 2014.
Published Online: June 2, 2014. doi:10.1001/jamaneurol.2014.1173.
Study concept and design: Ooms, Overeem, Olde Rikkert, Verbeek, Claassen.
Acquisition, analysis, or interpretation of data: Ooms, Overeem, Besse, Claassen.
Drafting of the manuscript: Ooms, Overeem, Verbeek, Claassen.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Ooms, Claassen.
Obtained funding: Verbeek, Claassen.
Administrative, technical, or material support: Overeem, Besse, Claassen.
Study supervision: Olde Rikkert, Verbeek, Claassen.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by Alzheimer Nederland (Dutch Alzheimer Foundation). Dr Overeem is the recipient of VIDI research grant 016.116.371 from the Netherlands Organization for Scientific Research.
Role of the Sponsor: Alzheimer Nederland (Dutch Alzheimer Foundation) had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Marijke Beenes, Radboud University Medical Center, performed the cerebrospinal fluid analysis of all participants. She received financial compensation.