Accepted for Publication: April 26, 2014.
Published Online: May 26, 2014. doi:10.1001/jamaneurol.2014.755.
Study concept and design: Michos, Carson, Schneider, Sharrett, Coker, Gross.
Acquisition, analysis, or interpretation of data: Michos, Carson, Schneider, Lutsey, Xing, Alonso, Coker, Gross, Post, Mosley, Gottesman.
Drafting of the manuscript: Michos.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Carson, Schneider, Xing, Gross.
Obtained funding: Michos, Coker, Mosley.
Administrative, technical, or material support: Coker, Gross.
Study supervision: Michos, Post.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke grant R01NS072243. Dr Schneider was supported by NIH/National Heart, Lung, and Blood Institute (NHLBI) training grant T32HL007024. The Atherosclerosis Risk in Communities (ARIC) study was carried out as a collaborative study supported by NHLBI contracts HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C. The ARIC Brain MRI study was supported by NIH/NHLBI grant R01-HL70825.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the staff and participants of the ARIC Brain MRI study for their important contributions.