We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Images in Neurology |

Magnetic Resonance Imaging Observations in Primary Central Nervous System Lymphoma

Justin T. Jordan, MD1; Scott Plotkin, MD, PhD1; Jorg Dietrich, MD, PhD1
[+] Author Affiliations
1Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital, Boston
JAMA Neurol. 2014;71(7):918-919. doi:10.1001/jamaneurol.2014.70.
Text Size: A A A
Published online


A 63-year-old woman with no medical history presented with two weeks of personality changes and social withdrawal, ignoring family, friends, and work. There were no apparent hallucinations or delusions. Her son brought her for evaluation after she began having difficulty recalling personal information and family names.

On examination, the patient was awake but inattentive, with a flat affect and no spontaneous speech. With prompting, all components of her language were otherwise normal. Her concentration was poor, as was remote and working memory. Her examination was otherwise normal for cranial nerves, strength, sensation, coordination, balance, and gait. Magnetic resonance imaging of the brain showed a symmetric enhancing lesion in the bilateral frontal lobes and anterior corpus callosum (Figure 1).

Figures in this Article


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.
Magnetic Resonance Imaging of the Brain

A, T2/fluid-attenuated inversion recovery symmetric hyperintensities are seen in the bilateral frontal lobes with callosal and forniceal thickening. B, Post-gadolinium T1-weighted images show homogeneous enhancement on coronal images. C, Restricted diffusion is seen on diffusion-weighted imaging. D, Apparent diffusion map hypointensity confirms restricted diffusion.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Stereotactic Biopsy of Brain Lesion Demonstrates Diffuse Large B-cell Lymphoma

A and B, Hematoxylin-eosin stain (original magnification x10 [A] and x40 [B]) of biopsy shows hypercellular, infiltrative characteristic. C, Tumor stains positively for CD-20.

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Collections