Accepted for Publication: April 2, 2014.
Published Online: May 19, 2014. doi:10.1001/jamaneurol.2014.895.
Study concept and design: Llufriu, Cree, Hauser, Pelletier.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Llufriu, Pelletier.
Critical revision of the manuscript for important intellectual content: Kornak, Ratiney, Oh, Brenneman, Cree, Sampat, Hauser, Nelson, Pelletier.
Statistical analysis: Kornak, Pelletier.
Obtained funding: Hauser, Pelletier.
Administrative, technical, or material support: Llufriu, Ratiney, Oh, Brenneman, Cree, Sampat, Hauser, Nelson, Pelletier.
Study supervision: Pelletier.
Conflict of Interest Disclosures: Dr Llufriu has served on scientific advisory boards for Teva, Biogen Idec, and Novartis. Dr Llufriu has also received honoraria for speaking from Merck Serono and Biogen Idec and funding for travel from Teva and Novartis. Drs Oh and Sampat are employees of Synarc Inc. Dr Cree has received personal compensation for consulting from Abbvie, Biogen Idec, EMD Serono, Genzyme/sanofi-aventis, MedImmune, Novartis, and Teva Neurosciences and has received contracted research support from Avanir, Acorda, Hoffman–La Roche, and Novartis. Dr Hauser was a (retired) scientific advisory board member for BioMarin and Receptos. Dr Pelletier has received personal compensation from CNS Imaging Consultant LLC. No other disclosures were reported.
Funding/Support: This study was supported by grants from the National Multiple Sclerosis Society (JF 2122-A, preliminary data set), the National Institutes of Health (NIH/National Institute of Neurological Disorders and Stroke R01-NS062885, confirmatory data set), GlaxoSmithKline, and Biogen Idec for clinical research and imaging data collection support.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank all the physicians at the University of California–San Francisco Multiple Sclerosis Center for referring patients to the study and all the participants for their contribution.