Accepted for Publication: February 18, 2014.
Published Online: May 19, 2014. doi:10.1001/jamaneurol.2014.463.
Study concept and design: Irani, Gelfand, Geschwind.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Irani.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Irani, Gelfand, Bettcher.
Obtained funding: Irani, Geschwind.
Administrative, technical, or material support: Irani, Singhal.
Study supervision: Irani, Geschwind.
Conflict of Interest Disclosures: Dr Irani reports being supported by the British Medical Association Vera Down Award, Epilepsy Research UK, and the National Institute for Health Research, Department of Health, United Kingdom (grant RDA/07/03/036). Dr Irani also reports being a co-applicant on a patent for discovery of VGKC-complex antigenic targets (including LGI1) and receives royalties. Dr Gelfand reports receiving support from the National Institutes of Health National Center for Advancing Translational Sciences (grant KL2TR000143), receiving honoraria from the National MS Society for patient education, and receiving compensation for medical legal consulting related to inflammatory demyelinating disease. Dr Geschwind reports being supported by the Michael J. Homer Family Foundation but has nothing to disclose related to this report. He has served as a consultant for MedaCorp, Gerson-Lehman Group, The Council of Advisors, Guidepoint Global, and Neurophage. No other disclosures were reported.
Funding/Support: This study was supported in part by a US-UK Fulbright Commission (Dr Irani), the Multiple Sclerosis Society (Dr Irani), and grants R01-AG031189 and P01-AG021601 from the National Institutes of Health/National Institute on Aging (Dr Geschwind).
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank our patients and their families for helping provide additional data and information. Angela Vincent, FRS (University of Oxford, Oxford, England), and Josep Dalmau, MD, PhD (University of Pennsylvania, Philadelphia, and University of Barcelona, Barcelona, Spain), performed antibody assays; neither received financial compensation. All authors have contributed to the patient identification.