Accepted for Publication: March 19, 2014.
Published Online: May 12, 2014. doi:10.1001/jamaneurol.2014.754.
Study concept and design: Kester, Wattjes, Scheltens, van der Flier.
Acquisition, analysis, or interpretation of data: Kester, Goos, Teunissen, Benedictus, Bouwman, Wattjes, Barkhof, Scheltens.
Drafting of the manuscript: Kester, Wattjes.
Critical revision of the manuscript for important intellectual content: Goos, Teunissen, Benedictus, Bouwman, Wattjes, Barkhof, van der Flier.
Statistical analysis: Kester, van der Flier.
Obtained funding: Kester, Scheltens.
Administrative, technical, or material support: Benedictus, Scheltens.
Study supervision: Teunissen, Wattjes, Barkhof, Scheltens, van der Flier.
Conflict of Interest Disclosures: Dr Teunissen serves as a member of the scientific advisory board of Innogenetics SA and Roche; received a speaker honorarium on a Tea-sponsored symposium; and received grants from the European Commission and the Alzheimer’s Drug Discovery Foundation. Dr Wattjes received consulting fees from Biogen Idec and Roche and he serves as an editorial board member of European Radiology. Dr Barkhof serves and has served on the advisory boards of Bayer-Schering Pharma, sanofi-aventis, Biogen Idec, Teva, Merck-Serono, Novartis, Jansen, and Roche; has received funding from the Dutch MS Society; and has been a speaker at symposia organized by the Serono Symposia Foundation. Dr Scheltens serves and has served on the advisory boards of Genentech, Novartis, Roche, Danone, Nutricia, Lilly, and Lundbeck. He has been a speaker at symposia organized by Lundbeck, Merz, Danone, Novartis, Roche, GE, and Genentech and receives no financial compensation for his activities. No other disclosures were reported.
Funding/Support: Dr Kester was supported by research fellowship WE 15-2012-03 from Alzheimer Nederland. Research performed at the Alzheimer Center, VU University Medical Center is part of the neurodegeneration research program of Neuroscience Campus Amsterdam. The Alzheimer Center, VU University Medical Center is supported by Alzheimer Nederland and the Stichting VU University Medical Center funds. The clinical database structure was developed with funding from Stichting Dioraphte.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Correction: This article was corrected on May 22, 2014, to fix a typographical error in the Abstract.